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• W3021223202 endingPage "e19881" @default.
• W3021223202 startingPage "e19881" @default.
• W3021223202 abstract "Background: Primary dysmenorrhea is common and troublesome. The comparative efficacy of over-the-counter analgesics (OTCAs) for dysmenorrhea is unclear. This study was aimed at conducting a network meta-analysis to assess the efficacy and safety of 5 OTCAs – naproxen, ibuprofen,diclofenac, aspirin, and ketoprofen – in patients with primary dysmenorrhea. Methods: The study was registered with PROSPERO (number: CRD42019133556). The search strategy involved a review of PubMed, Embase, Cochrane Library, Web of Science, and CINAHL for relative randomized controlled trials of the 5 analgesics from the date of database establishment to July 2019. The outputs are presented as odds ratios (ORs), their corresponding 95% confidence intervals (CIs), and the surface under the cumulative ranking area (SUCRA) probabilities. Results: Thirty-five trials with 4383 participants were included in our study. As for efficacy outcomes, all the included analgesics except aspirin were more effective than placebo in treating dysmenorrhea [naproxen (OR 3.99, 95% CI 2.18–7.30), ibuprofen (OR 10.08, 95% CI 3.29–30.85), diclofenac (OR 11.82, 95% CI 2.66–52.48), and ketoprofen (OR 5.12, 95% CI 1.57–16.69). The OTCAs were superior to the placebo in terms of pain relief in primary dysmenorrhea. Aspirin was less effective than ibuprofen (OR 0.17, 95% CI 0.04–0.73) and diclofenac (OR 1.17, 95% CI 0.02–0.85). The SUCRA curves showed that diclofenac and ibuprofen were the most and second most effective (85.1% and 83.8%, respectively), followed by ketoprofen, naproxen, and aspirin. Regarding safety, there was no significant difference between the 5 OTCAs included and the placebo. Diclofenac versus ibuprofen (OR 4.31, 95% CI 1.18–15.67), ketoprofen versus diclofenac (OR 0.18, 95% CI 0.04–0.78), and ketoprofen versus aspirin (OR 0.41, 95% CI 0.18–0.97) presented statistically significant differences. Ketoprofen and ibuprofen were ranked the best (SUCRA 90.6% and 79.6%), followed by naproxen, aspirin, and diclofenac. Conclusion: Considering the efficacy and safety, ibuprofen is recommended as the optimal OTCA for primary dysmenorrhea. Further well-designed studies that directly compare these analgesics are needed to support our conclusion." @default.
• W3021223202 created "2020-05-13" @default.
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• W3021223202 date "2020-05-01" @default.
• W3021223202 modified "2023-10-10" @default.
• W3021223202 title "Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea" @default.
• W3021223202 cites W1483114350 @default.
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• W3021223202 cites W1590780092 @default.
• W3021223202 cites W1601208950 @default.
• W3021223202 cites W173239477 @default.
• W3021223202 cites W188438927 @default.
• W3021223202 cites W1969411746 @default.
• W3021223202 cites W1973992611 @default.
• W3021223202 cites W1976542259 @default.
• W3021223202 cites W1977343977 @default.
• W3021223202 cites W1979669185 @default.
• W3021223202 cites W1992015419 @default.
• W3021223202 cites W1994274798 @default.
• W3021223202 cites W1994548146 @default.
• W3021223202 cites W2004542254 @default.
• W3021223202 cites W2010955833 @default.
• W3021223202 cites W2014086781 @default.
• W3021223202 cites W2014672787 @default.
• W3021223202 cites W2024507924 @default.
• W3021223202 cites W2035477546 @default.
• W3021223202 cites W2040749057 @default.
• W3021223202 cites W2041459920 @default.
• W3021223202 cites W2044847681 @default.
• W3021223202 cites W2046761294 @default.
• W3021223202 cites W2052355330 @default.
• W3021223202 cites W205366962 @default.
• W3021223202 cites W2058906018 @default.
• W3021223202 cites W2062626394 @default.
• W3021223202 cites W2066664366 @default.
• W3021223202 cites W2080197694 @default.
• W3021223202 cites W2082958848 @default.
• W3021223202 cites W2085612038 @default.
• W3021223202 cites W2091053622 @default.
• W3021223202 cites W2091808438 @default.
• W3021223202 cites W2092854192 @default.
• W3021223202 cites W2097561978 @default.
• W3021223202 cites W2109711640 @default.
• W3021223202 cites W2118548533 @default.
• W3021223202 cites W2137695415 @default.
• W3021223202 cites W2150668453 @default.
• W3021223202 cites W2168787751 @default.
• W3021223202 cites W2170495053 @default.
• W3021223202 cites W2405175138 @default.
• W3021223202 cites W2424679295 @default.
• W3021223202 cites W2463473983 @default.
• W3021223202 cites W2566499580 @default.
• W3021223202 cites W2614640673 @default.
• W3021223202 cites W2752853294 @default.
• W3021223202 cites W2762813876 @default.
• W3021223202 cites W2785557395 @default.
• W3021223202 cites W2796691051 @default.
• W3021223202 cites W2802045991 @default.
• W3021223202 cites W2878218651 @default.
• W3021223202 cites W2885830024 @default.
• W3021223202 cites W2886291913 @default.
• W3021223202 cites W2892480397 @default.
• W3021223202 cites W2897111496 @default.
• W3021223202 cites W2898658288 @default.
• W3021223202 cites W2898956426 @default.
• W3021223202 cites W2901242774 @default.
• W3021223202 cites W2909562300 @default.
• W3021223202 cites W2921506721 @default.
• W3021223202 cites W2935190828 @default.
• W3021223202 cites W2938786888 @default.
• W3021223202 cites W2940263335 @default.
• W3021223202 cites W2944967890 @default.
• W3021223202 cites W40273712 @default.
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• W3021223202 doi "https://doi.org/10.1097/md.0000000000019881" @default.
• W3021223202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7220209" @default.
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