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• W3021250375 startingPage "1" @default.
• W3021250375 abstract "Lyssaviruses are ancient, but underappreciated, stymied in part by superstitions and ignorance, fragments of records over thousands of years, technical limitations, academic conservatism, and classical biopolitical thought. Once believed as a single entity, rabies is caused by > 17 lyssavirus species. Wildlife, particularly bats, perpetuate lyssaviruses, as agents of a disease of nature. Eurasia was the likely focus for the original spread of canine rabies. Canine domestication, adaptation of wildlife rabies virus to dogs, subsequent host shifts back to wild carnivores, and global translocation of rabid dogs during 15th century colonization provided the underpinnings to the current burden and distribution of rabies at a landscape scale. Inferred relationships of rabies to animal bites, the characteristic neurological signs and inevitability of death had a major influence on scientific thought and applications toward a crucial understanding of viral pathogenesis, diagnosis, epidemiology, prevention, and control throughout the 19th–20th centuries. Today, a renewed focus on a “Zero by 30” plan has the potential for the greatest impact upon the global elimination of human rabies via dogs in modern history. Owing to progress obtained over the past century, all tools are available for demonstration of this goal over the next decade in an applied One Health capacity. To this end, history informs the present, representative of threats born of complacency and globalization, as well as actualization of promises that international collaboration and technology offer in response to one of the oldest neglected tropical diseases." @default.
• W3021250375 created "2020-05-13" @default.
• W3021250375 creator A5012181714 @default.
• W3021250375 creator A5026559156 @default.
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• W3021250375 creator A5076353319 @default.
• W3021250375 creator A5088316173 @default.
• W3021250375 date "2020-01-01" @default.
• W3021250375 modified "2023-10-09" @default.
• W3021250375 title "A history of rabies—The foundation for global canine rabies elimination" @default.
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