Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021271176> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3021271176 abstract "Selenium is a trace element associated with the activity of the antioxidant enzyme glutathione peroxidase and is considered to be a protective agent against free radicals through enhanced enzyme activity. Associations between low selenium and increased risk in various disease indices including cancer, cardiovascular disease, reproduction and neonatal health, and asthma have been reported. The limited studies on selenium and cognitive function or Alzheimer's disease, however, have not reached unequivocal conclusions. To examine the association between selenium levels and cognitive function in the elderly. A cross–sectional survey of 2000 rural Chinese age 65 and over from two provinces in China was conducted using the Community Screening Instrument for Dementia, CERAD Word List Learning test, a 14–item story recall, Animal Fluency test, and IU Token Test. Over seventy percent of study participants have lived in the same village since birth. Nail samples were collected and analyzed for selenium contents. Food frequency questionnaires were administrated while local food samples were collected and analyzed for selenium content. APOE genotype was determined using blood samples collected on filter cards. Analysis of covariance models were used to estimate the association between selenium levels measured in nail samples and from food intake and cognitive test scores adjusted for age, gender, education and APOE genotype. Lower selenium levels measured in nail samples and from food intake were significantly associated with poor cognitive function as measured by various cognitive tests. Standardized beta coefficients range from 0.06 to 0.24 on all tests (p<0.01 for all) adjusted for age, gender, education level and APOE genotype. The APO ϵ4 allele was not significantly associated with any cognitive measures and there is no significant interaction between APOE and selenium levels. Our results support the hypothesis that low selenium level is associated with poor cognitive function. Longitudinal follow–up of this cohort will help to establish whether selenium levels affect the rate of cognitive decline associated with aging." @default.
- W3021271176 created "2020-05-13" @default.
- W3021271176 creator A5004565067 @default.
- W3021271176 creator A5012334998 @default.
- W3021271176 creator A5024131822 @default.
- W3021271176 creator A5025669167 @default.
- W3021271176 creator A5026983826 @default.
- W3021271176 creator A5031301688 @default.
- W3021271176 creator A5039635718 @default.
- W3021271176 creator A5044804019 @default.
- W3021271176 creator A5045164695 @default.
- W3021271176 creator A5054445385 @default.
- W3021271176 creator A5057297514 @default.
- W3021271176 creator A5078514456 @default.
- W3021271176 creator A5080069557 @default.
- W3021271176 creator A5082036476 @default.
- W3021271176 date "2006-07-01" @default.
- W3021271176 modified "2023-09-27" @default.
- W3021271176 title "P3-124: Selenium and cognitive function in rural elderly Chinese" @default.
- W3021271176 doi "https://doi.org/10.1016/j.jalz.2006.05.1392" @default.
- W3021271176 hasPublicationYear "2006" @default.
- W3021271176 type Work @default.
- W3021271176 sameAs 3021271176 @default.
- W3021271176 citedByCount "0" @default.
- W3021271176 crossrefType "journal-article" @default.
- W3021271176 hasAuthorship W3021271176A5004565067 @default.
- W3021271176 hasAuthorship W3021271176A5012334998 @default.
- W3021271176 hasAuthorship W3021271176A5024131822 @default.
- W3021271176 hasAuthorship W3021271176A5025669167 @default.
- W3021271176 hasAuthorship W3021271176A5026983826 @default.
- W3021271176 hasAuthorship W3021271176A5031301688 @default.
- W3021271176 hasAuthorship W3021271176A5039635718 @default.
- W3021271176 hasAuthorship W3021271176A5044804019 @default.
- W3021271176 hasAuthorship W3021271176A5045164695 @default.
- W3021271176 hasAuthorship W3021271176A5054445385 @default.
- W3021271176 hasAuthorship W3021271176A5057297514 @default.
- W3021271176 hasAuthorship W3021271176A5078514456 @default.
- W3021271176 hasAuthorship W3021271176A5080069557 @default.
- W3021271176 hasAuthorship W3021271176A5082036476 @default.
- W3021271176 hasConcept C118552586 @default.
- W3021271176 hasConcept C126322002 @default.
- W3021271176 hasConcept C169900460 @default.
- W3021271176 hasConcept C178790620 @default.
- W3021271176 hasConcept C185592680 @default.
- W3021271176 hasConcept C2775838275 @default.
- W3021271176 hasConcept C2776151105 @default.
- W3021271176 hasConcept C2778760513 @default.
- W3021271176 hasConcept C2779135701 @default.
- W3021271176 hasConcept C553756173 @default.
- W3021271176 hasConcept C71924100 @default.
- W3021271176 hasConcept C74909509 @default.
- W3021271176 hasConcept C99454951 @default.
- W3021271176 hasConceptScore W3021271176C118552586 @default.
- W3021271176 hasConceptScore W3021271176C126322002 @default.
- W3021271176 hasConceptScore W3021271176C169900460 @default.
- W3021271176 hasConceptScore W3021271176C178790620 @default.
- W3021271176 hasConceptScore W3021271176C185592680 @default.
- W3021271176 hasConceptScore W3021271176C2775838275 @default.
- W3021271176 hasConceptScore W3021271176C2776151105 @default.
- W3021271176 hasConceptScore W3021271176C2778760513 @default.
- W3021271176 hasConceptScore W3021271176C2779135701 @default.
- W3021271176 hasConceptScore W3021271176C553756173 @default.
- W3021271176 hasConceptScore W3021271176C71924100 @default.
- W3021271176 hasConceptScore W3021271176C74909509 @default.
- W3021271176 hasConceptScore W3021271176C99454951 @default.
- W3021271176 hasIssue "3S_Part_13" @default.
- W3021271176 hasLocation W30212711761 @default.
- W3021271176 hasOpenAccess W3021271176 @default.
- W3021271176 hasPrimaryLocation W30212711761 @default.
- W3021271176 hasRelatedWork W1967052070 @default.
- W3021271176 hasRelatedWork W1970317500 @default.
- W3021271176 hasRelatedWork W1971220289 @default.
- W3021271176 hasRelatedWork W2023258154 @default.
- W3021271176 hasRelatedWork W2051695364 @default.
- W3021271176 hasRelatedWork W2075166913 @default.
- W3021271176 hasRelatedWork W2082016521 @default.
- W3021271176 hasRelatedWork W2413925306 @default.
- W3021271176 hasRelatedWork W2414547378 @default.
- W3021271176 hasRelatedWork W2499838175 @default.
- W3021271176 hasVolume "2" @default.
- W3021271176 isParatext "false" @default.
- W3021271176 isRetracted "false" @default.
- W3021271176 magId "3021271176" @default.
- W3021271176 workType "article" @default.