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- W3021300041 abstract "Publisher SummaryThis chapter focuses on cardiovascular system. This chapter illustrates that the recognition of drug-induced structural changes in cardiac tissues in man has been hampered by the problems of differentiating drug-induced injury from naturally occurring cardiovascular disease. There have increasing concerns voiced about the serious cardiac events, including sudden deaths produced by not only psychotropic drugs, but also a range of other noncardiovascular drugs, including antimalarials, antifungal drugs, antibacterial agents, and certain histamine H1-receptor antagonists. In view of the variety and complexity of factors that lead to vascular damage in the context of a limited repertoire of responses of blood vessels to injury, it is prudent to use a simple classification in preclinical toxicity studies. It is important to carefully define the distribution and size of vessels involved and to provide a precise histopathological description of individual lesions. In general pulmonary response to hypoxia is similar among different mammalian species, age, strain, and species-related susceptibility to hypoxia is variable. Finally, it should be noted that pulmonary vascular endothelial hypertrophy and hyperplasia, as well as arterial medial thickening has been shown to occur in rats infused simply with large quantities of isotonic saline solution, presumably as a response to the increased fluid flow or turbulence in the pulmonary circulation." @default.
- W3021300041 created "2020-05-13" @default.
- W3021300041 creator A5053371660 @default.
- W3021300041 date "2000-01-01" @default.
- W3021300041 modified "2023-09-23" @default.
- W3021300041 title "Cardiovascular System" @default.
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