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- W3021304979 abstract "Abstract A significant circadian rhythm was demonstrated for acute toxicity of phenobarbital (PB) in mice housed with the condition of a 12 hr light-dark cycle and given food and water ad lib. The highest mortality was found in mice injected at the midlight period. PB-induced sleeping time was shorter in mice injected at the middark period than in mice injected at the midlight period. Elimination of plasma PB was faster and plasma PB concentration at the time of awakening was higher in mice injected at the middark period. When feeding time was restricted to the light period for 2 wks, the acrophase of PB toxicity rhythm was shifted, with highest mortality following injection at the middark period. PB-induced sleeping time, elimination of plasma PB and plasma PB concentration at the time of awakening were also significantly influenced by the time-restricted feeding schedule. The similar finding was also demonstrated in apomorphine(APM)-induced stereotypy of rats. These results suggest that the cause of the circadian rhythm of actions of these drugs can be attributed to the rhythms of both the sensitivity in the central nervous system and pharmacokinetics, showing that feeding is a more important determinant than the light-dark condition in producing the circadian rhythm in these drugs. In man, amitriptyline(AMT) kinetics differed in the absorption phase between morning and evening dosing after a single oral administration. Neither the mean elimination half-life nor the area under the serum concentration-time curve for AMT differed between morning and evening dosing. The AMT-induced anticholinergic action measured by salivary flow and subjective sedative effects were more prominent in the morning. The results suggest the significance of chronopharmacokinetic aspects of the drug in some clinical situations." @default.
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- W3021304979 date "1983-01-01" @default.
- W3021304979 modified "2023-09-25" @default.
- W3021304979 title "Pharmacokinetic aspects of chronopharmacology" @default.
- W3021304979 doi "https://doi.org/10.1016/s0021-5198(19)60183-6" @default.
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