FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021307284> ?p ?o ?g. }

• W3021307284 endingPage "6484" @default.
• W3021307284 startingPage "6472" @default.
• W3021307284 abstract "Abstract Tetralogy of Fallot (TOF) is the most common complex congenital heart disease (CHD) with uncertain cause. Although long non‐coding RNAs (lncRNAs) have been implicated in heart development and several CHDs, their role in TOF is not well understood. This study aimed to investigate how dysregulated lncRNAs contribute to TOF. Using Gene Expression Omnibus data mining, bioinformatics analysis and clinical heart tissue sample detecting, we identified a novel antisense lncRNA TBX5‐AS1:2 with unknown function that was significantly down‐regulated in injured cardiac tissues from TOF patients. LncRNA TBX5‐AS1:2 was mainly located in the nucleus of the human embryonic kidney 293 (HEK293T) cells and formed an RNA‐RNA double‐stranded structure in the overlapping region with its sense mRNA T‐box transcription factor 5 ( TBX5 ), which is an important regulator in heart development. Knock‐down of lncRNA TBX5‐AS1:2 via promoter hypermethylation reduced TBX5 expression at both the mRNA and protein levels by affecting its mRNA stability through RNA‐RNA interaction. Moreover, lncRNA TBX5‐AS1:2 knock‐down inhibited the proliferation of HEK293T cells. In conclusion, these results indicated that lncRNA TBX5‐AS1:2 may be involved in TOF by affecting cell proliferation by targeting TBX5 ." @default.
• W3021307284 created "2020-05-13" @default.
• W3021307284 creator A5009592212 @default.
• W3021307284 creator A5012042498 @default.
• W3021307284 creator A5027822382 @default.
• W3021307284 creator A5027883397 @default.
• W3021307284 creator A5042328954 @default.
• W3021307284 creator A5052590910 @default.
• W3021307284 creator A5057319499 @default.
• W3021307284 creator A5066843240 @default.
• W3021307284 creator A5072172819 @default.
• W3021307284 date "2020-05-05" @default.
• W3021307284 modified "2023-09-29" @default.
• W3021307284 title "Hypermethylation‐mediated down‐regulation of lncRNA TBX5‐AS1:2 in Tetralogy of Fallot inhibits cell proliferation by reducing <i>TBX5</i> expression" @default.
• W3021307284 cites W1535517524 @default.
• W3021307284 cites W1602695373 @default.
• W3021307284 cites W1976302894 @default.
• W3021307284 cites W1979662111 @default.
• W3021307284 cites W1980306443 @default.
• W3021307284 cites W1986257473 @default.
• W3021307284 cites W1988896110 @default.
• W3021307284 cites W1990654990 @default.
• W3021307284 cites W1995946981 @default.
• W3021307284 cites W1998135118 @default.
• W3021307284 cites W2015707272 @default.
• W3021307284 cites W2033841429 @default.
• W3021307284 cites W2050982262 @default.
• W3021307284 cites W2059062907 @default.
• W3021307284 cites W2064870273 @default.
• W3021307284 cites W2066996651 @default.
• W3021307284 cites W2086116864 @default.
• W3021307284 cites W2086507603 @default.
• W3021307284 cites W2088069070 @default.
• W3021307284 cites W2088443710 @default.
• W3021307284 cites W2099014322 @default.
• W3021307284 cites W2105028177 @default.
• W3021307284 cites W2108727475 @default.
• W3021307284 cites W2113721993 @default.
• W3021307284 cites W2116056916 @default.
• W3021307284 cites W2119614635 @default.
• W3021307284 cites W2135837543 @default.
• W3021307284 cites W2136625706 @default.
• W3021307284 cites W2160890377 @default.
• W3021307284 cites W2161673104 @default.
• W3021307284 cites W2169055756 @default.
• W3021307284 cites W2215941422 @default.
• W3021307284 cites W2217164039 @default.
• W3021307284 cites W2270976853 @default.
• W3021307284 cites W2280074825 @default.
• W3021307284 cites W2289788816 @default.
• W3021307284 cites W2398456308 @default.
• W3021307284 cites W2487556046 @default.
• W3021307284 cites W2542049135 @default.
• W3021307284 cites W2551322419 @default.
• W3021307284 cites W2591171709 @default.
• W3021307284 cites W2596653957 @default.
• W3021307284 cites W2596744052 @default.
• W3021307284 cites W2615891385 @default.
• W3021307284 cites W2729948611 @default.
• W3021307284 cites W2753074635 @default.
• W3021307284 cites W2760056442 @default.
• W3021307284 cites W2765199691 @default.
• W3021307284 cites W2777574440 @default.
• W3021307284 cites W2781723573 @default.
• W3021307284 cites W2788382713 @default.
• W3021307284 cites W2791637983 @default.
• W3021307284 cites W2803425338 @default.
• W3021307284 cites W2887690453 @default.
• W3021307284 cites W2889074368 @default.
• W3021307284 cites W2891524643 @default.
• W3021307284 cites W2894764101 @default.
• W3021307284 cites W2906590590 @default.
• W3021307284 cites W2908832460 @default.
• W3021307284 cites W2912484632 @default.
• W3021307284 doi "https://doi.org/10.1111/jcmm.15298" @default.
• W3021307284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7294119" @default.
• W3021307284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32368852" @default.
• W3021307284 hasPublicationYear "2020" @default.
• W3021307284 type Work @default.
• W3021307284 sameAs 3021307284 @default.
• W3021307284 citedByCount "15" @default.
• W3021307284 countsByYear W30213072842021 @default.
• W3021307284 countsByYear W30213072842022 @default.
• W3021307284 countsByYear W30213072842023 @default.
• W3021307284 crossrefType "journal-article" @default.
• W3021307284 hasAuthorship W3021307284A5009592212 @default.
• W3021307284 hasAuthorship W3021307284A5012042498 @default.
• W3021307284 hasAuthorship W3021307284A5027822382 @default.
• W3021307284 hasAuthorship W3021307284A5027883397 @default.
• W3021307284 hasAuthorship W3021307284A5042328954 @default.
• W3021307284 hasAuthorship W3021307284A5052590910 @default.
• W3021307284 hasAuthorship W3021307284A5057319499 @default.
• W3021307284 hasAuthorship W3021307284A5066843240 @default.
• W3021307284 hasAuthorship W3021307284A5072172819 @default.
• W3021307284 hasBestOaLocation W30213072841 @default.
• W3021307284 hasConcept C104317684 @default.
• W3021307284 hasConcept C105580179 @default.
• W3021307284 hasConcept C145103041 @default.

• next