FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021309188> ?p ?o ?g. }

• W3021309188 abstract "Abstract Introduction: TSH-secreting pituitary adenomas (TSHomas) are the rarest form of pituitary tumors. Transsphenoidal surgery is usually the treatment of choice, although somatostatin analogs (SSAs) are a reasonable and effective option. Pregnancy in the setting of TSHomas is an even rarer situation, scarcely reported in the literature. We report the long-term management of a TSHoma treated with octreotide who developed a successful pregnancy. Case Report: A 16 year-old girl was diagnosed in 2003 with a TSHoma after presenting with goiter, weight loss, tremors and headache. Laboratory tests showed central hyperthyroidism: TSH 2,78 uUI/ml (0,27-4,02); T4 22,4 ng/dl (4,8-12,7); T3 430 ng/dl (72-170) and pituitary MRI showed a 2 cm adenoma. TRH test showed a blunted response, and TSH did not suppress after T3 test, with hormonal values returning to normal range after octreotide administration. Since 2003 the patient have been treated with Octreotide LAR 20 mg. At 34 years-old she expressed her willingness to become pregnant. At this time, hyperthyroidism was controlled (TSH 1.79; T4 12; T3 181) and the pituitary adenoma was smaller (1.2 cm) while on octreotide LAR 20 mg every 8 weeks. Before conceiving, she did a visual field test that was normal and measured α-subunit (αSU), which was slightly increased (0.73 ug/l, upper limit of normal [ULN] &lt; 0.6 ug/l). After 3 months, she successfully conceived. During first trimester, thyroid function remained controlled. The patient was asymptomatic and the fetus was developing as expected. From 18 weeks on, T3 started to increase (T3 227 ng/dl– ULN 200 ng/dl) with normal T4 and FT4 and without symptoms or fetal repercussion. Alpha-subunit increased to 9.5 ug/l. Throughout pregnancy, octreotide was administered in the same pre-pregnancy dosage. At 37 weeks, αSU was 272.314 ug/l after 1:100 dilution (ULN &lt; 604 ug/;) and HCG was 38.316. The patient developed gestational diabetes mellitus that was managed with diet counseling. Spontaneous delivery occurred at 39 weeks, birth weight was 3160g, APGAR 9/10. Newborn thyroid function was normal. Three months after delivery, the patient complained of hand tremors and hair loss. New laboratory tests revealed TSH 6,7 uUI/ml (ULN &lt;4.5); T4 12,9 (ULN &lt;12); T4L 3,3 (ULN &lt;1.7); T3 247 (ULN &lt;200) and αSU was 513 ug/l (ULN&lt; 0.6). Octreotide LAR 20 mg interval was decreased to every 6 weeks. Currently, ten months after delivery, the patients is asymptomatic and thyroid function is normal. Conclusion: TSHoma appears to be safely managed throughout pregnancy without the need of stopping octreotide, which seems not to adversely affect outcomes for the mother and the fetus. This case also illustrates the long-term management (16 years) of TSHoma with octreotide with excellent hormonal and structural response." @default.
• W3021309188 created "2020-05-13" @default.
• W3021309188 creator A5005367225 @default.
• W3021309188 creator A5074364100 @default.
• W3021309188 creator A5077980540 @default.
• W3021309188 creator A5083730245 @default.
• W3021309188 creator A5091334732 @default.
• W3021309188 date "2020-04-01" @default.
• W3021309188 modified "2023-09-23" @default.
• W3021309188 title "SAT-253 Long-Term Management and Successful Pregnancy of a Patient with a TSH Secreting Macroadenoma Treated with Octreotide" @default.
• W3021309188 doi "https://doi.org/10.1210/jendso/bvaa046.1906" @default.
• W3021309188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7207386" @default.
• W3021309188 hasPublicationYear "2020" @default.
• W3021309188 type Work @default.
• W3021309188 sameAs 3021309188 @default.
• W3021309188 citedByCount "0" @default.
• W3021309188 crossrefType "journal-article" @default.
• W3021309188 hasAuthorship W3021309188A5005367225 @default.
• W3021309188 hasAuthorship W3021309188A5074364100 @default.
• W3021309188 hasAuthorship W3021309188A5077980540 @default.
• W3021309188 hasAuthorship W3021309188A5083730245 @default.
• W3021309188 hasAuthorship W3021309188A5091334732 @default.
• W3021309188 hasBestOaLocation W30213091881 @default.
• W3021309188 hasConcept C126322002 @default.
• W3021309188 hasConcept C134018914 @default.
• W3021309188 hasConcept C187212893 @default.
• W3021309188 hasConcept C2776216936 @default.
• W3021309188 hasConcept C2776297358 @default.
• W3021309188 hasConcept C2777428134 @default.
• W3021309188 hasConcept C2777910003 @default.
• W3021309188 hasConcept C2779234561 @default.
• W3021309188 hasConcept C2779318953 @default.
• W3021309188 hasConcept C2779653919 @default.
• W3021309188 hasConcept C2781025020 @default.
• W3021309188 hasConcept C4134927 @default.
• W3021309188 hasConcept C54355233 @default.
• W3021309188 hasConcept C71315377 @default.
• W3021309188 hasConcept C71924100 @default.
• W3021309188 hasConcept C86803240 @default.
• W3021309188 hasConcept C90924648 @default.
• W3021309188 hasConceptScore W3021309188C126322002 @default.
• W3021309188 hasConceptScore W3021309188C134018914 @default.
• W3021309188 hasConceptScore W3021309188C187212893 @default.
• W3021309188 hasConceptScore W3021309188C2776216936 @default.
• W3021309188 hasConceptScore W3021309188C2776297358 @default.
• W3021309188 hasConceptScore W3021309188C2777428134 @default.
• W3021309188 hasConceptScore W3021309188C2777910003 @default.
• W3021309188 hasConceptScore W3021309188C2779234561 @default.
• W3021309188 hasConceptScore W3021309188C2779318953 @default.
• W3021309188 hasConceptScore W3021309188C2779653919 @default.
• W3021309188 hasConceptScore W3021309188C2781025020 @default.
• W3021309188 hasConceptScore W3021309188C4134927 @default.
• W3021309188 hasConceptScore W3021309188C54355233 @default.
• W3021309188 hasConceptScore W3021309188C71315377 @default.
• W3021309188 hasConceptScore W3021309188C71924100 @default.
• W3021309188 hasConceptScore W3021309188C86803240 @default.
• W3021309188 hasConceptScore W3021309188C90924648 @default.
• W3021309188 hasIssue "Supplement_1" @default.
• W3021309188 hasLocation W30213091881 @default.
• W3021309188 hasLocation W30213091882 @default.
• W3021309188 hasOpenAccess W3021309188 @default.
• W3021309188 hasPrimaryLocation W30213091881 @default.
• W3021309188 hasRelatedWork W172455046 @default.
• W3021309188 hasRelatedWork W1981300577 @default.
• W3021309188 hasRelatedWork W2010872713 @default.
• W3021309188 hasRelatedWork W2043804243 @default.
• W3021309188 hasRelatedWork W2049972387 @default.
• W3021309188 hasRelatedWork W2141385068 @default.
• W3021309188 hasRelatedWork W2146333229 @default.
• W3021309188 hasRelatedWork W2235992327 @default.
• W3021309188 hasRelatedWork W2273027564 @default.
• W3021309188 hasRelatedWork W869484964 @default.
• W3021309188 hasVolume "4" @default.
• W3021309188 isParatext "false" @default.
• W3021309188 isRetracted "false" @default.
• W3021309188 magId "3021309188" @default.
• W3021309188 workType "article" @default.