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- W3021341259 abstract "This chapter explores the relationship between the immune system and the gametes by examining both the morphological and immunological bases for protection and the enormous potential for destruction. The fertilization process begins when spermatozoa released from the male enter into the environment of the oocyte (external fertilization) or are deposited into the female reproductive tract (internal fertilization); and it ends when the zygote is formed. Mammalian spermatozoa are, therefore, deposited into the female reproductive tract to initiate the process of fertilization. The reproductive tract rather quickly transports spermatozoa to the site of fertilization, usually in the upper regions of the oviduct, through peristaltic smooth muscle contractions in the wall and with some help from the sperm's own motility. In humans, the necessary protection of the spermatozoa may be afforded by the lack of human leukocyte antigen (HLA) markers on the surface of the spermatozoa The study of the immunobiology of gametes gives us an understanding of the mechanisms that operate to protect the gametes and prevent destruction in both males and females. These mechanisms are rooted in the morphology of the testis and ovary and in the significant developmental difference in the time of meiotic prophase between the sexes. The immune system has evolved to deal with this reality by prioritizing the T cell response in a network of cytokines that most often directs the response away from destruction. The presence of antigamete antibodies in either males or females is not inherently dangerous and may in fact indicate in many cases an adaptation to deal with the late-arriving antigens of the reproductive system." @default.
- W3021341259 created "2020-05-13" @default.
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- W3021341259 date "2002-01-01" @default.
- W3021341259 modified "2023-10-12" @default.
- W3021341259 title "Gamete Immunobiology" @default.
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- W3021341259 doi "https://doi.org/10.1016/b978-012311629-1/50014-0" @default.
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