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- W3021343182 abstract "Publisher SummaryGlucocorticoid-induced osteoporosis (GIO) is one of the most frequent forms of osteoporosis in men, for which the awareness is still suboptimal. Peculiar epidemiological (underlying diseases) and pathophysiological (hypogonadism) aspects characterize GIO in men. Glucocorticoids have both direct and indirect effects on bone. The central pathophysiological mechanism of bone loss during long-term use of glucocorticoids is reduced bone formation, due to actions that affect osteoblast differentiation and function. However, during the first phases of glucocorticoid excess, significant increase in bone resorption (ultimately leading to the observed early increase of risk of fractures) may occur. With regard to diagnostic as well as therapeutic measures there are no specific recommendations in males with GIO with the exception of testosterone replacement. Moreover, data concerning bone mineral density cut-offs and treatment efficacy are often translated from the experiences in females more than based on sex-specific evidences." @default.
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- W3021343182 date "2010-01-01" @default.
- W3021343182 modified "2023-09-25" @default.
- W3021343182 title "Glucocorticoid-induced Osteoporosis" @default.
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- W3021343182 doi "https://doi.org/10.1016/b978-0-12-374602-3.00034-1" @default.
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