Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021366174> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3021366174 abstract "ABSTRACT Introduction COVID-19 disproportionately affects those with comorbidities and the elderly. Hypertension is the most common pre-existing condition amongst COVID-19 patients. Upregulation of the renin-angiotensin-aldosterone system (RAAS) is common in hypertensive patients and may promote inflammation and ensuing cytokine storm in COVID-19. It is unknown whether RAAS inhibition with ACE1 inhibitors or angiotensin-receptor blockers (ARB) can be harmful or beneficial. Methods Within Hackensack Meridian Health network, the largest healthcare provider in New Jersey, we performed a retrospective, multicenter, convenience sampling study of hospitalized COVID-19 patients. Demographics, clinical characteristics, treatments, and outcomes were manually abstracted. Fishers exact tests, and logistic regression were performed. Results Among 3017 hospitalized COVID-19 patients, 1584 (52.5%) carried a diagnosis of hypertension. In the discharged or deceased cohort, the overall mortality was significantly increased at 35% vs 13% among COVID-19 patients with hypertension. However, when adjusted for age, the effect of hypertension on mortality was greatly diminished, with a reduction in odds-ratio by over half; and completely disappeared when adjusted for other major covariates. The mortality rates were lower for hypertensive patients prescribed ACE1 (27%, p=0.001) or ARBs (33%, p=0.12) compared to other anti-hypertensive agents (39%) in the unadjusted analyses. RAAS inhibitor therapy appeared protective compared to other anti-hypertensive agents (p=0.001). Conclusions While our results are limited by the retrospective nature of our study and by potential confounders, our data argue against a harmful effect of RAAS inhibition and support the HFSA/AHA/ACC joint statement recommending continuing ACE1 and ARB therapy in hypertensive COVID-19 patients." @default.
- W3021366174 created "2020-05-13" @default.
- W3021366174 creator A5007239934 @default.
- W3021366174 creator A5011797345 @default.
- W3021366174 creator A5025036628 @default.
- W3021366174 creator A5029633779 @default.
- W3021366174 creator A5036078876 @default.
- W3021366174 creator A5046306389 @default.
- W3021366174 creator A5062968216 @default.
- W3021366174 date "2020-04-29" @default.
- W3021366174 modified "2023-09-23" @default.
- W3021366174 title "Hypertension and Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19" @default.
- W3021366174 cites W2800798998 @default.
- W3021366174 cites W3003217347 @default.
- W3021366174 cites W3013302817 @default.
- W3021366174 cites W3016535995 @default.
- W3021366174 cites W3033263367 @default.
- W3021366174 doi "https://doi.org/10.1101/2020.04.24.20077388" @default.
- W3021366174 hasPublicationYear "2020" @default.
- W3021366174 type Work @default.
- W3021366174 sameAs 3021366174 @default.
- W3021366174 citedByCount "27" @default.
- W3021366174 countsByYear W30213661742020 @default.
- W3021366174 countsByYear W30213661742021 @default.
- W3021366174 countsByYear W30213661742022 @default.
- W3021366174 crossrefType "posted-content" @default.
- W3021366174 hasAuthorship W3021366174A5007239934 @default.
- W3021366174 hasAuthorship W3021366174A5011797345 @default.
- W3021366174 hasAuthorship W3021366174A5025036628 @default.
- W3021366174 hasAuthorship W3021366174A5029633779 @default.
- W3021366174 hasAuthorship W3021366174A5036078876 @default.
- W3021366174 hasAuthorship W3021366174A5046306389 @default.
- W3021366174 hasAuthorship W3021366174A5062968216 @default.
- W3021366174 hasBestOaLocation W30213661741 @default.
- W3021366174 hasConcept C126322002 @default.
- W3021366174 hasConcept C151956035 @default.
- W3021366174 hasConcept C156957248 @default.
- W3021366174 hasConcept C167135981 @default.
- W3021366174 hasConcept C198710026 @default.
- W3021366174 hasConcept C2778525890 @default.
- W3021366174 hasConcept C2779134260 @default.
- W3021366174 hasConcept C3008058167 @default.
- W3021366174 hasConcept C524204448 @default.
- W3021366174 hasConcept C71924100 @default.
- W3021366174 hasConcept C77350462 @default.
- W3021366174 hasConcept C84393581 @default.
- W3021366174 hasConceptScore W3021366174C126322002 @default.
- W3021366174 hasConceptScore W3021366174C151956035 @default.
- W3021366174 hasConceptScore W3021366174C156957248 @default.
- W3021366174 hasConceptScore W3021366174C167135981 @default.
- W3021366174 hasConceptScore W3021366174C198710026 @default.
- W3021366174 hasConceptScore W3021366174C2778525890 @default.
- W3021366174 hasConceptScore W3021366174C2779134260 @default.
- W3021366174 hasConceptScore W3021366174C3008058167 @default.
- W3021366174 hasConceptScore W3021366174C524204448 @default.
- W3021366174 hasConceptScore W3021366174C71924100 @default.
- W3021366174 hasConceptScore W3021366174C77350462 @default.
- W3021366174 hasConceptScore W3021366174C84393581 @default.
- W3021366174 hasLocation W30213661741 @default.
- W3021366174 hasOpenAccess W3021366174 @default.
- W3021366174 hasPrimaryLocation W30213661741 @default.
- W3021366174 hasRelatedWork W1501762993 @default.
- W3021366174 hasRelatedWork W2016647631 @default.
- W3021366174 hasRelatedWork W2045469404 @default.
- W3021366174 hasRelatedWork W2047608102 @default.
- W3021366174 hasRelatedWork W2077998387 @default.
- W3021366174 hasRelatedWork W2078291669 @default.
- W3021366174 hasRelatedWork W2088522435 @default.
- W3021366174 hasRelatedWork W2088763604 @default.
- W3021366174 hasRelatedWork W2126797993 @default.
- W3021366174 hasRelatedWork W2382651085 @default.
- W3021366174 isParatext "false" @default.
- W3021366174 isRetracted "false" @default.
- W3021366174 magId "3021366174" @default.
- W3021366174 workType "article" @default.