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• W3021368082 abstract "Age of onset estimates are crucial to clinical management and designing disease prevention studies. For many diseases, age is the primary risk factor. Age of onset is censored if a person is unaffected. Two different modeling philosophies are possible: to assume a mixture of susceptible and nonsusceptible individuals in the population, or to assume that all individuals are susceptible and would become affected if only they lived long enough. Variability of age of onset as a function of exposures can be modeled through the hazard. Designs possible to estimate age of onset parameters are: case—control family studies, kin—cohort studies, and the study of high-risk families. Age-specific penetrances can be estimated using a likelihood, pseudolikelihood, marginal likelihood, weighted score, or the method of moments.Keywords:age-specific penetrance;age-specific risk;cumulative risk;cumulative incidence;hazard;genetic counselling" @default.
• W3021368082 created "2020-05-13" @default.
• W3021368082 creator A5023411724 @default.
• W3021368082 date "2014-09-29" @default.
• W3021368082 modified "2023-09-25" @default.
• W3021368082 title "Age‐of‐Onset Estimation" @default.
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• W3021368082 doi "https://doi.org/10.1002/9781118445112.stat05355" @default.
• W3021368082 hasPublicationYear "2014" @default.
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