FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021386911> ?p ?o ?g. }

• W3021386911 abstract "Abstract Meningiomas correspond to 37% of intracranial tumors and are considered the second most common neoplasm of the central nervous system in adults. Most of them are benign with slow growth pattern, common from the fifth decade, more frequent in women and with high recurrence rates. In tumors, there is a reduction in the efficiency of DNA error repair, allowing the proliferation of tumor cells. In this work, we evaluated the protein expression of markers involved in cell synthesis (cyclin D1) and repair of DNA errors (MUTYH, XPF, and XPG) in meningiomas. To date, this is the first study to use the immunohistochemical technique in the evaluation of these repair proteins, relating them to clinical data, tumor variables and recurrence-regrowth free survival. 85 samples were included in the study, patients with a mean age of 52 + 13.3 years, 68% female, in proportion 2:1. Most cases were classified as grade I (79%), meningothelial subtype (38%) and transitional (25%). Regarding surgery, 59% of the patients underwent total resection. Regarding location, the most common was the peripheral (62.2%). Most tumors (64%) were larger than 3cm, with a mean of 3.6±2cm. The median recurrence-regrowth free survival was 67 months (95% CI:57.8-76.6). According to the Kaplan-Meier curve, the recurrence-regrowth free survival rate was 94.4% at 1 year, 76.6% at 2 years and 64.7% at 3 years and 49.4% at 5 years. Grades II and III were prognostic factors for tumor recurrence-regrowth (p&lt;0.05). Cyclin D1 was positive in 92%, 77% in grade I and 23% in grades II and III. A statistically significant relationship was found between cyclin D1 and tumor grade (p = 0.001), with higher expression in grade II and III. Repair proteins were expressed in most meningiomas. MUTYH (63.5%), 43.5% in grades I and 20% in grades II and III, with a significant relationship between grades II and III and, expression 10-50% (p=0.02). Significant association was observed with MUTYH (p=0.001) and XPF (p=0.019). XPF and XPG were associated with grades II and III (p=0.002 and p&lt;0.001) and XPF with size &gt;3cm (p=0.03). There was a positive correlation between XPF and XPG (p= 0.02) and between MUTYH and XPF (p=0.003). XP proteins were related to recurrence-regrowth (p=0.04), but not with recurrence-regrowth free survival. Our results demonstrate the activation of repair pathways and increased cell synthesis in grades II and III in meningiomas. Cellular synthesis and DNA repair markers are important tools to broaden knowledge about the biological behavior of meningiomas." @default.
• W3021386911 created "2020-05-13" @default.
• W3021386911 creator A5003751974 @default.
• W3021386911 creator A5023388723 @default.
• W3021386911 creator A5041617088 @default.
• W3021386911 creator A5060740074 @default.
• W3021386911 creator A5065448751 @default.
• W3021386911 creator A5079803285 @default.
• W3021386911 creator A5081839174 @default.
• W3021386911 creator A5085484483 @default.
• W3021386911 date "2020-04-01" @default.
• W3021386911 modified "2023-09-26" @default.
• W3021386911 title "SAT-122 Expression of Cell Synthesis and Dna Repair Markers in Meningioma Recurrence or Regrowth" @default.
• W3021386911 doi "https://doi.org/10.1210/jendso/bvaa046.741" @default.
• W3021386911 hasPublicationYear "2020" @default.
• W3021386911 type Work @default.
• W3021386911 sameAs 3021386911 @default.
• W3021386911 citedByCount "0" @default.
• W3021386911 crossrefType "journal-article" @default.
• W3021386911 hasAuthorship W3021386911A5003751974 @default.
• W3021386911 hasAuthorship W3021386911A5023388723 @default.
• W3021386911 hasAuthorship W3021386911A5041617088 @default.
• W3021386911 hasAuthorship W3021386911A5060740074 @default.
• W3021386911 hasAuthorship W3021386911A5065448751 @default.
• W3021386911 hasAuthorship W3021386911A5079803285 @default.
• W3021386911 hasAuthorship W3021386911A5081839174 @default.
• W3021386911 hasAuthorship W3021386911A5085484483 @default.
• W3021386911 hasBestOaLocation W30213869111 @default.
• W3021386911 hasConcept C126322002 @default.
• W3021386911 hasConcept C141071460 @default.
• W3021386911 hasConcept C142724271 @default.
• W3021386911 hasConcept C143998085 @default.
• W3021386911 hasConcept C204232928 @default.
• W3021386911 hasConcept C2779160599 @default.
• W3021386911 hasConcept C3019822344 @default.
• W3021386911 hasConcept C71924100 @default.
• W3021386911 hasConcept C90924648 @default.
• W3021386911 hasConceptScore W3021386911C126322002 @default.
• W3021386911 hasConceptScore W3021386911C141071460 @default.
• W3021386911 hasConceptScore W3021386911C142724271 @default.
• W3021386911 hasConceptScore W3021386911C143998085 @default.
• W3021386911 hasConceptScore W3021386911C204232928 @default.
• W3021386911 hasConceptScore W3021386911C2779160599 @default.
• W3021386911 hasConceptScore W3021386911C3019822344 @default.
• W3021386911 hasConceptScore W3021386911C71924100 @default.
• W3021386911 hasConceptScore W3021386911C90924648 @default.
• W3021386911 hasLocation W30213869111 @default.
• W3021386911 hasLocation W30213869112 @default.
• W3021386911 hasOpenAccess W3021386911 @default.
• W3021386911 hasPrimaryLocation W30213869111 @default.
• W3021386911 hasRelatedWork W11712036 @default.
• W3021386911 hasRelatedWork W13808466 @default.
• W3021386911 hasRelatedWork W14862101 @default.
• W3021386911 hasRelatedWork W15311094 @default.
• W3021386911 hasRelatedWork W15685115 @default.
• W3021386911 hasRelatedWork W18454073 @default.
• W3021386911 hasRelatedWork W3988885 @default.
• W3021386911 hasRelatedWork W529119 @default.
• W3021386911 hasRelatedWork W8169096 @default.
• W3021386911 hasRelatedWork W1842356 @default.
• W3021386911 isParatext "false" @default.
• W3021386911 isRetracted "false" @default.
• W3021386911 magId "3021386911" @default.
• W3021386911 workType "article" @default.