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• W3021387420 endingPage "78" @default.
• W3021387420 startingPage "67" @default.
• W3021387420 abstract "Airway remodeling is defined as a process of sustained disruption and modification of structural cells and tissues leading to the development of new airway wall morphology. Airway structural changes in chronic obstructive pulmonary disease (COPD) are well recognized. Among these, the principal changes involve airway fibrosis, an elevation in smooth muscle mass, mucous metaplasia, and glandular hypertrophy, in addition to less well-defined alterations of the bronchial vasculature and nerves. The outcome is a very abnormal airway wall. In asthma, segmental and subsegmental bronchial walls are thickened over their entire size range. In COPD, though, only the inner wall area of the large airways becomes thicker. Remodeling is part of the primary pathology of the disease and results in a number of clinical consequences for both asthma and COPD, such as bronchial hyperresponsiveness, airway inflammation, and smooth muscle reactivity. It is important to acknowledge that early therapy prevents, to a limited extent, remodeling but established structural changes are steroid insensitive. With advancing research, effective strategies in the future would focus directly on remodeling pathways that could lead to the emergence of an “anti-remodeling” agent." @default.
• W3021387420 created "2020-05-13" @default.
• W3021387420 creator A5001877690 @default.
• W3021387420 creator A5032192970 @default.
• W3021387420 creator A5089020623 @default.
• W3021387420 date "2002-01-01" @default.
• W3021387420 modified "2023-10-18" @default.
• W3021387420 title "Airway Remodeling" @default.
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