Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021404995> ?p ?o ?g. }
- W3021404995 endingPage "192" @default.
- W3021404995 startingPage "175" @default.
- W3021404995 abstract "Osteoclasts are multinucleated giant cells that resorb bone, and develop from hematopoietic cells of the monocytemacrophage lineage. Another essential factor for osteoclastogenesis is receptor activator of nuclear factor κB ligand (RANKL). Development of osteoclasts has opened a wide new area in bone biology focused on the investigation of the molecular mechanism of osteoclast development and function. Osteoblasts/stromal cells, through the expression of RANKL and M-CSF, are involved throughout the osteoclast lifetime of their differentiation, survival, fusion, and activation. OPG produced by osteoblasts/stromal cells is an important negative regulator of osteoclast differentiation and function. RANKL(–/–) mice and RANK(–/–) mice have shown similar features of osteopetrosis with a complete absence of osteoclasts in bone. Furthermore, gain-of-function mutations of RANK have been found in patients suffering from familial expansile osteolysis and familial Paget's disease of bone. Loss-of function mutation of OPG also results in juvenile Paget's disease in bone. In addition, loss-of-function mutations in the gene encoding RANKL have been found in patients with autosomal recessive osteopetrosis whose bone biopsy specimens lacked osteoclasts. These findings confirm that the RANKL–RANK interaction is indispensable for osteoclastogenesis, not only in mice, but also in humans. Finally, studies have also shown that inflammatory cytokines, TNF α and IL-1, can substitute for RANKL in inducing osteoclast differentiation and function. These results suggest that in addition to RANKL, inflammatory cytokines play important roles in osteoclastic bone resorption under pathological conditions." @default.
- W3021404995 created "2020-05-13" @default.
- W3021404995 creator A5002464903 @default.
- W3021404995 creator A5034320377 @default.
- W3021404995 creator A5048320728 @default.
- W3021404995 date "2008-01-01" @default.
- W3021404995 modified "2023-10-15" @default.
- W3021404995 title "Osteoclast Generation" @default.
- W3021404995 cites W1529510901 @default.
- W3021404995 cites W1534645474 @default.
- W3021404995 cites W1536343809 @default.
- W3021404995 cites W1549053710 @default.
- W3021404995 cites W1650001464 @default.
- W3021404995 cites W1677043489 @default.
- W3021404995 cites W1907841101 @default.
- W3021404995 cites W1963690512 @default.
- W3021404995 cites W1964066819 @default.
- W3021404995 cites W1968796843 @default.
- W3021404995 cites W1971470705 @default.
- W3021404995 cites W1971720206 @default.
- W3021404995 cites W1972001482 @default.
- W3021404995 cites W1974810780 @default.
- W3021404995 cites W1977830503 @default.
- W3021404995 cites W1986392434 @default.
- W3021404995 cites W1988699576 @default.
- W3021404995 cites W1995906897 @default.
- W3021404995 cites W1997504364 @default.
- W3021404995 cites W1997508587 @default.
- W3021404995 cites W1999201913 @default.
- W3021404995 cites W1999985403 @default.
- W3021404995 cites W2000647744 @default.
- W3021404995 cites W2000736649 @default.
- W3021404995 cites W2004465286 @default.
- W3021404995 cites W2007341912 @default.
- W3021404995 cites W2008467935 @default.
- W3021404995 cites W2019146941 @default.
- W3021404995 cites W2029322422 @default.
- W3021404995 cites W2030261305 @default.
- W3021404995 cites W2031874549 @default.
- W3021404995 cites W2032421685 @default.
- W3021404995 cites W2036368043 @default.
- W3021404995 cites W2040032327 @default.
- W3021404995 cites W2041138285 @default.
- W3021404995 cites W2042589950 @default.
- W3021404995 cites W2043651158 @default.
- W3021404995 cites W2043992170 @default.
- W3021404995 cites W2046390154 @default.
- W3021404995 cites W2047076201 @default.
- W3021404995 cites W2048299560 @default.
- W3021404995 cites W2050954943 @default.
- W3021404995 cites W2051241300 @default.
- W3021404995 cites W2055166353 @default.
- W3021404995 cites W2063676540 @default.
- W3021404995 cites W2063781710 @default.
- W3021404995 cites W2064603645 @default.
- W3021404995 cites W2065784567 @default.
- W3021404995 cites W2066385294 @default.
- W3021404995 cites W2073614902 @default.
- W3021404995 cites W2078050928 @default.
- W3021404995 cites W2080647358 @default.
- W3021404995 cites W2081071690 @default.
- W3021404995 cites W2089354715 @default.
- W3021404995 cites W2094402463 @default.
- W3021404995 cites W2097304380 @default.
- W3021404995 cites W2102948981 @default.
- W3021404995 cites W2105059159 @default.
- W3021404995 cites W2106766464 @default.
- W3021404995 cites W2110097720 @default.
- W3021404995 cites W2111239144 @default.
- W3021404995 cites W2114162483 @default.
- W3021404995 cites W2114935509 @default.
- W3021404995 cites W2114982159 @default.
- W3021404995 cites W2116610925 @default.
- W3021404995 cites W2116828514 @default.
- W3021404995 cites W2117482844 @default.
- W3021404995 cites W2119413986 @default.
- W3021404995 cites W2119695863 @default.
- W3021404995 cites W2120837197 @default.
- W3021404995 cites W2122720369 @default.
- W3021404995 cites W2124036292 @default.
- W3021404995 cites W2125802340 @default.
- W3021404995 cites W2126913097 @default.
- W3021404995 cites W2128289981 @default.
- W3021404995 cites W2129651548 @default.
- W3021404995 cites W2130443006 @default.
- W3021404995 cites W2130847389 @default.
- W3021404995 cites W2131357215 @default.
- W3021404995 cites W2132933661 @default.
- W3021404995 cites W2134006720 @default.
- W3021404995 cites W2136183395 @default.
- W3021404995 cites W2136357996 @default.
- W3021404995 cites W2139996507 @default.
- W3021404995 cites W2140473585 @default.
- W3021404995 cites W2140813706 @default.
- W3021404995 cites W2147510409 @default.
- W3021404995 cites W2149248348 @default.
- W3021404995 cites W2153869151 @default.
- W3021404995 cites W2156803578 @default.