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- W3021421061 abstract "With the gradual development of modern medicine the overall survival and quality of life of patients with chronic kidney disease significantly improved. Kidney transplantation significantly enhanced the treatment of end-stage renal disease patients. However, many transplanted kidneys are lost due to chronic graft changes caused by immunosupression therapy or occurence of late chronic immunologic response. The family of Wnt (wingless- type MMTV integration site family) genes are constituted of 19, till now, described members. Some of this proteins are present in kidney development but also in the process of kidney injury and reparation. Due to this published results it is assumed that the same molecules responsible for the regulation of nephrogenesis also participates in the patophysiology of tubulointerstitial kidney disease. It is still not clear which Wnt gene is responsible for protection and which for damage especially in transplanted kidneys. The aim of this study was to analyze whether Wnt 4 expression is increased in transplanted kidneys compared to healthy kdiney samples and is it dependable of different causes of graftectomies. In this study we have included 59 kidney transplanted patients from deceased donors and 24 nephrectomized patients due to localised kidney tumours as a control group. The obtained results did not confirmed our hypothesis. On the contrary, the Wnt 4 expression was significantly lower in the kidney transplanted patients group compared to healthy kidney tissue samples which was strongly correlated with age. Although the Wnt 4 expression was correlated with higher age, its most independent and significant correlation was with longer cold ischemia time. This are, at least to our knowledge, the first results which reported higher Wnt 4 expression and better kidney graft survival and its possible role as an factor in kidney graft regeneration especially in prolonged ischemia time and acute tubular necrosis. These results emphasize the importance on future studies of different Wnt receptors agonists as a novel therapy in treating tissue ichemia injuries." @default.
- W3021421061 created "2020-05-13" @default.
- W3021421061 creator A5034550108 @default.
- W3021421061 date "2019-03-06" @default.
- W3021421061 modified "2023-09-24" @default.
- W3021421061 title "Izraženost Wnt 4 u presađenim bubrezima [Expression of Wnt 4 in transplant kidneys]" @default.
- W3021421061 hasPublicationYear "2019" @default.
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