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• W3021426009 abstract "Publisher SummaryAnimal models are extensively used in the discovery of the primary events that trigger asthma and chronic obstructive pulmonary disease (COPD). Animal models are also used to guide research into pharmacological interventions for the treatment of asthma and COPD. This chapter reviews the mouse models of asthma induced by ovalbumin sensitization and challenge and the animal models of chronic bronchitis as created by exposure to high concentrations of SO2 gas. The chapter focuses on changes in the mechanics of the airways because it is the airway obstruction associated with asthma and COPD that ultimately causes lung dysfunction, disability, and death. In humans, asthma is characterized by intermittent reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although there is no specific animal that spontaneously mimics all these traits, a syndrome with some features of asthma can be observed in certain horses and cats and in the Basenji-greyhound cross of dogs. As a result, many investigators have developed animal models in which an asthma-like phenotype is induced by some intervention. The strategy most often employed for this purpose is allergen sensitization and challenge. Chronic bronchitis is characterized by cough and mucus hypersecretion, airway obstruction, and airway hyperresponsiveness. Animal models have been developed that mimic many of these aspects. The methods used to generate these models include chronic exposure to high concentrations of SO2 gas, endotoxin, and sodium metabisulfite." @default.
• W3021426009 created "2020-05-13" @default.
• W3021426009 creator A5049845466 @default.
• W3021426009 date "2002-01-01" @default.
• W3021426009 modified "2023-09-27" @default.
• W3021426009 title "Animal Models" @default.
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• W3021426009 doi "https://doi.org/10.1016/b978-012079028-9/50083-1" @default.
• W3021426009 hasPublicationYear "2002" @default.
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