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- W3021457229 endingPage "413" @default.
- W3021457229 startingPage "400" @default.
- W3021457229 abstract "Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophages (MDM), that means the principal obstacle to HIV cure. MDM are widely distributed in all tissues and organs, including central system nervous (CNS) where they represent the most frequent HIV-infected cells that means the principal obstacle to HIV cure. Current FDA-approved antiretroviral drugs target viral reverse transcriptase, protease, integrase, and entry processes (coreceptor or fusion blockade). It is desirable to continue to develop new antiretrovirals directed against alternative targets in the virus lifecycle in order to further optimize therapeutic options, overcome resistance to existing medications, and potentially contribute to the elimination of viral reservoirs.This review provides a comprehensive overview of the activity of antiretroviral drugs (classical and upcoming) in monocytes-derived macrophages (MDM). Defining the antiviral activity of these drugs in this important cellular HIV-1 reservoir provides crucial hints about their efficacy in HIV-1 infected patients." @default.
- W3021457229 created "2020-05-13" @default.
- W3021457229 creator A5006689393 @default.
- W3021457229 creator A5018496506 @default.
- W3021457229 creator A5080320465 @default.
- W3021457229 creator A5080590367 @default.
- W3021457229 date "2020-05-06" @default.
- W3021457229 modified "2023-10-14" @default.
- W3021457229 title "Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages" @default.
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