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• W3021467859 abstract "You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I (MP46)1 Apr 2020MP46-02 METAGENOMIC ANALYSIS OF THE GENITOURINARY MICROBIOME OF POSTMENOPAUSAL WOMEN WITH RECURRENT UTI Michael Neugent, Neha Hulyalkar, Ashwani Kumar, Vivian Nguyen, Amy Kuprasertkul, Jorge Fuentes, Chao Xing, Philippe Zimmern, Kelli Palmer, and Nicole De Nisco* Michael NeugentMichael Neugent More articles by this author , Neha HulyalkarNeha Hulyalkar More articles by this author , Ashwani KumarAshwani Kumar More articles by this author , Vivian NguyenVivian Nguyen More articles by this author , Amy KuprasertkulAmy Kuprasertkul More articles by this author , Jorge FuentesJorge Fuentes More articles by this author , Chao XingChao Xing More articles by this author , Philippe ZimmernPhilippe Zimmern More articles by this author , Kelli PalmerKelli Palmer More articles by this author , and Nicole De Nisco*Nicole De Nisco* More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000901.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Recurrent UTI (rUTI), defined ≥3 UTIs per year, is a growing clinical concern disproportionally affecting postmenopausal (PM) women. Changes in the genitourinary (GU) microbiome after UTI may predispose PM women to rUTI. The composition and function of the GU microbiome of PM women has not been systematically analyzed. The goal of this cross-sectional study was to utilize whole-genome metagenomic sequencing (WGMS) to define and compare the GU microbiomes of three cohorts of PM women (Never UTI, Remittent rUTI, and Relapsed rUTI). METHODS: Following IRB approval and patient consent, WGMS was performed on clean-catch urine from PM women passing strict inclusion criteria for uncomplicated rUTI. Women were sorted into cohorts by clinical history of rUTI. “Never UTI” (n=10): no clinical UTI history, “Remittent rUTI” (n=15): rUTI history, no current UTI, “Relapsed rUTI (n=14): rUTI history, current UTI. DNA was purified from urine and prepared libraries were sequenced on an Illumina NextSeq 500 generating paired-end reads that were analyzed with custom bioinformatic pipelines for taxonomic enrichment and functional profiling of the detected metagenomes. RESULTS: Our results indicate that the diversity of the GU microbiome is diminished in the “Relapsed rUTI” with respect to the “Never UTI” and “Remittent rUTI” cohorts. We also found a robust association between exogenous estrogen use and enrichment of the genus Lactobacillus in the GU microbiomes of women in “Never UTI” and “Remittent rUTI” cohorts. Women not taking estrogen consistently had low or undetectable levels of Lactobacillus. Our preliminary analysis also revealed differential enrichment of putative protective (e.g. L. crispatus) and non-protective (e.g. L. inners) species in “Never UTI” versus “Remittent rUTI” cohorts. CONCLUSIONS: We present the first systematic WGMS analysis of the GU microbiome in PM women.This cross-sectional study has revealed a strong association between exogenous estrogen use and enrichment of the genus Lactobacillus. Certain members of the genus Lactobacillus are protective within the cervicovaginal microbiome and may play a similar role in the GU microbiome. Continuing work will explore this association by functional analysis of cohort metagenomes and metabolomics. Source of Funding: Cecil H. and Ida Green Chair in Systems Biology Science © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e673-e673 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael Neugent More articles by this author Neha Hulyalkar More articles by this author Ashwani Kumar More articles by this author Vivian Nguyen More articles by this author Amy Kuprasertkul More articles by this author Jorge Fuentes More articles by this author Chao Xing More articles by this author Philippe Zimmern More articles by this author Kelli Palmer More articles by this author Nicole De Nisco* More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W3021467859 title "MP46-02 METAGENOMIC ANALYSIS OF THE GENITOURINARY MICROBIOME OF POSTMENOPAUSAL WOMEN WITH RECURRENT UTI" @default.
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