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- W3021472011 abstract "This chapter deals with the secreted proteinases from Candida. Candida albicans is a diploid, dimorphic fungus that exists in two dominant morphological forms: the yeast and the hyphal. As a human pathogen, Candida can cause diseases ranging from mild, transient, and readily curable infections to chronic, severe, and frequently fatal systemic conditions. This chapter focuses on the most recent data on pathogenicity and differential expression of the various SAPs, and also on the unique structural differences encountered in the proximity of the active site among the different members of SAPs from C. albicans and C. tropicalis. A detailed analysis reveals that although the various secreted enzymes are highly homologous, the residues next to the active site in the different SAP1–6 of C. albicans present significant variability. This diversity can be initially divided into two groups: SAP1–3 and SAP4–6. Further analysis indicates that individual subsite specificity also exists within each SAP." @default.
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- W3021472011 date "1999-01-01" @default.
- W3021472011 modified "2023-09-27" @default.
- W3021472011 title "The Secreted Proteinases from Candida" @default.
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- W3021472011 doi "https://doi.org/10.1016/b978-012420510-9/50031-4" @default.
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