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- W3021519462 abstract "Genomic imprinting, a specific type of inherited epigenetic regulation, controls a number of genes with important functions in the hypothalamus and its associated neuroendocrinology. Imprinted genes are expressed monoallelically, dependent on the parental origin of the allele, whereby maternally or paternally inherited DNA methylation marks determine gene activity. In this chapter, we provide an overview of imprinted genes with roles in the hypothalamic regulation of whole-body energy homeostasis, neuroendocrine hormone functions, and circadian rhythmicity. As an example for imprinted genes that impact on the central regulation of energy balance, we describe the Gnas locus in more detail, since it generates parental allele-specific gene products with antagonistic roles in energy expenditure and sympathetic nervous system activity. Several human neuroendocrine disorders are caused by defects in imprinted genes as described here for Prader–Willi Syndrome and Angelman Syndrome. Furthermore, we outline methodological approaches for the investigation of DNA methylation marks and allelic gene expression, including bisulfite conversion of DNA and pyrosequencing. Recent technological advances to resolve methylation and allelic expression at the single-cell level are introduced." @default.
- W3021519462 created "2020-05-13" @default.
- W3021519462 creator A5053582271 @default.
- W3021519462 creator A5070079391 @default.
- W3021519462 date "2020-01-01" @default.
- W3021519462 modified "2023-10-16" @default.
- W3021519462 title "Imprinted Genes and Hypothalamic Function" @default.
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- W3021519462 doi "https://doi.org/10.1007/978-3-030-40002-6_10" @default.
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