Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021526455> ?p ?o ?g. }
- W3021526455 endingPage "3301" @default.
- W3021526455 startingPage "3301" @default.
- W3021526455 abstract "Parkinson’s disease (PD) is the second most common neurodegenerative disease; it is characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of neuronal inclusions, mainly consisting of α-synuclein (α-syn) fibrils in the affected regions. The prion-like property of the pathological forms of α-syn transmitted via neuronal circuits has been considered inherent in the nature of PD. Thus, one of the potential targets in terms of PD prevention is the suppression of α-syn conversion from the functional form to pathological forms. Recent studies suggested that α-syn interacts with synaptic vesicle membranes and modulate the synaptic functions. A series of studies suggest that transient interaction of α-syn as multimers with synaptic vesicle membranes composed of phospholipids and other lipids is required for its physiological function, while an α-syn-lipid interaction imbalance is believed to cause α-syn aggregation and the resultant pathological α-syn conversion. Altered lipid metabolisms have also been implicated in the modulation of PD pathogenesis. This review focuses on the current literature reporting the role of lipids, especially phospholipids, and lipid metabolism in α-syn dynamics and aggregation processes." @default.
- W3021526455 created "2020-05-13" @default.
- W3021526455 creator A5014705038 @default.
- W3021526455 creator A5022616909 @default.
- W3021526455 creator A5053000890 @default.
- W3021526455 date "2020-05-07" @default.
- W3021526455 modified "2023-10-15" @default.
- W3021526455 title "Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease" @default.
- W3021526455 cites W1489681252 @default.
- W3021526455 cites W1517181973 @default.
- W3021526455 cites W1546304837 @default.
- W3021526455 cites W1606762250 @default.
- W3021526455 cites W175460259 @default.
- W3021526455 cites W1859468577 @default.
- W3021526455 cites W1964353444 @default.
- W3021526455 cites W1965095016 @default.
- W3021526455 cites W1965778124 @default.
- W3021526455 cites W1968251608 @default.
- W3021526455 cites W1969130034 @default.
- W3021526455 cites W1971009462 @default.
- W3021526455 cites W1971116939 @default.
- W3021526455 cites W1972715091 @default.
- W3021526455 cites W1972862786 @default.
- W3021526455 cites W1977044612 @default.
- W3021526455 cites W1977246689 @default.
- W3021526455 cites W1978659393 @default.
- W3021526455 cites W1979444935 @default.
- W3021526455 cites W1979944790 @default.
- W3021526455 cites W1982823673 @default.
- W3021526455 cites W1987490764 @default.
- W3021526455 cites W1989732798 @default.
- W3021526455 cites W1990473626 @default.
- W3021526455 cites W1990974805 @default.
- W3021526455 cites W1991241547 @default.
- W3021526455 cites W1994577657 @default.
- W3021526455 cites W1995281235 @default.
- W3021526455 cites W1996637092 @default.
- W3021526455 cites W1999159261 @default.
- W3021526455 cites W1999213641 @default.
- W3021526455 cites W1999221820 @default.
- W3021526455 cites W2005379695 @default.
- W3021526455 cites W2006463991 @default.
- W3021526455 cites W2009573330 @default.
- W3021526455 cites W2012890515 @default.
- W3021526455 cites W2012973109 @default.
- W3021526455 cites W2013313629 @default.
- W3021526455 cites W2013939032 @default.
- W3021526455 cites W2014194922 @default.
- W3021526455 cites W2014299620 @default.
- W3021526455 cites W2022428567 @default.
- W3021526455 cites W2023048174 @default.
- W3021526455 cites W2023245921 @default.
- W3021526455 cites W2029028848 @default.
- W3021526455 cites W2031365272 @default.
- W3021526455 cites W2031687154 @default.
- W3021526455 cites W2036386995 @default.
- W3021526455 cites W2037948191 @default.
- W3021526455 cites W2040042139 @default.
- W3021526455 cites W2040706104 @default.
- W3021526455 cites W2044407202 @default.
- W3021526455 cites W2044428616 @default.
- W3021526455 cites W2044908785 @default.
- W3021526455 cites W2046885195 @default.
- W3021526455 cites W2049825478 @default.
- W3021526455 cites W2050647292 @default.
- W3021526455 cites W2052204832 @default.
- W3021526455 cites W2054490148 @default.
- W3021526455 cites W2059261643 @default.
- W3021526455 cites W2060177986 @default.
- W3021526455 cites W2066833882 @default.
- W3021526455 cites W2068244727 @default.
- W3021526455 cites W2068602144 @default.
- W3021526455 cites W2068955183 @default.
- W3021526455 cites W2069269058 @default.
- W3021526455 cites W2070199486 @default.
- W3021526455 cites W2070953412 @default.
- W3021526455 cites W2071087722 @default.
- W3021526455 cites W2072427499 @default.
- W3021526455 cites W2073079404 @default.
- W3021526455 cites W2073745970 @default.
- W3021526455 cites W2074085543 @default.
- W3021526455 cites W2075180304 @default.
- W3021526455 cites W2075944712 @default.
- W3021526455 cites W2076078146 @default.
- W3021526455 cites W2077910689 @default.
- W3021526455 cites W2079378641 @default.
- W3021526455 cites W2081748488 @default.
- W3021526455 cites W2082315075 @default.
- W3021526455 cites W2083488981 @default.
- W3021526455 cites W2088694143 @default.
- W3021526455 cites W2090048744 @default.
- W3021526455 cites W2091265794 @default.
- W3021526455 cites W2091589417 @default.
- W3021526455 cites W2094241924 @default.
- W3021526455 cites W2094697500 @default.
- W3021526455 cites W2096165225 @default.
- W3021526455 cites W2104445336 @default.
- W3021526455 cites W2111797988 @default.