FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021543552> ?p ?o ?g. }

• W3021543552 abstract "Abstract Aims Evidence links markers of systemic inflammation and heart failure (HF) with ventricular arrhythmias (VA) and/or death. Biomarker levels, and the risk they indicate, may vary over time. We evaluated the utility of serial laboratory measurements of inflammatory biomarkers and HF, using time-dependent analysis. Methods and results We prospectively enrolled ambulatory patients with left ventricular ejection fraction (LVEF) ≤35% and a primary-prevention implanted cardioverter-defibrillator (ICD). Levels of established inflammatory biomarkers [C-reactive protein, erythrocyte sedimentation rate (ESR), suppression of tumourigenicity 2 (ST2), tumour necrosis factor alpha (TNF-α)] and brain natriuretic peptide (BNP) were assessed at 3-month intervals for 1 year. We assessed relationships between biomarkers modelled as time-dependent variables, VA, and death. Among 196 patients (66±14 years, LVEF 23±8%), 33 experienced VA, and 18 died. Using only baseline values, BNP predicted VA, and both BNP and ST2 predicted death. Using serial measurements at 3-month intervals, time-varying BNP independently predicted VA, and time-varying ST2 independently predicted death. C-statistic analysis revealed no significant benefit to repeated testing compared with baseline-only measurement. C-reactive protein, ESR, and TNF-α, either at baseline or over time, did not predict either endpoint. Conclusion In stable ambulatory patients with systolic cardiomyopathy and an ICD, BNP predicts ventricular tachyarrhythmia, and ST2 predicts death. Repeated laboratory measurements over a year’s time do not improve risk stratification beyond baseline measurement alone. Clinical Trial Registration Clinicaltrials.gov NCT01892462 (https://clinicaltrials.gov/ct2/show/NCT01892462)." @default.
• W3021543552 created "2020-05-13" @default.
• W3021543552 creator A5027991164 @default.
• W3021543552 creator A5033688106 @default.
• W3021543552 creator A5044089228 @default.
• W3021543552 creator A5054895333 @default.
• W3021543552 creator A5065192665 @default.
• W3021543552 creator A5066778872 @default.
• W3021543552 creator A5067797706 @default.
• W3021543552 creator A5073988415 @default.
• W3021543552 date "2020-05-01" @default.
• W3021543552 modified "2023-09-24" @default.
• W3021543552 title "Utility of serial measurement of biomarkers of cardiovascular stress and inflammation in systolic dysfunction" @default.
• W3021543552 cites W1505958453 @default.
• W3021543552 cites W1511973058 @default.
• W3021543552 cites W1915089052 @default.
• W3021543552 cites W1993160453 @default.
• W3021543552 cites W2035288438 @default.
• W3021543552 cites W2042834694 @default.
• W3021543552 cites W2044461846 @default.
• W3021543552 cites W2064821822 @default.
• W3021543552 cites W2071675848 @default.
• W3021543552 cites W2071695679 @default.
• W3021543552 cites W2084301400 @default.
• W3021543552 cites W2084656663 @default.
• W3021543552 cites W2108683648 @default.
• W3021543552 cites W2114599876 @default.
• W3021543552 cites W2131550246 @default.
• W3021543552 cites W2542064944 @default.
• W3021543552 cites W2546606462 @default.
• W3021543552 cites W2748400555 @default.
• W3021543552 cites W2766427323 @default.
• W3021543552 doi "https://doi.org/10.1093/europace/euaa075" @default.
• W3021543552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32357207" @default.
• W3021543552 hasPublicationYear "2020" @default.
• W3021543552 type Work @default.
• W3021543552 sameAs 3021543552 @default.
• W3021543552 citedByCount "0" @default.
• W3021543552 crossrefType "journal-article" @default.
• W3021543552 hasAuthorship W3021543552A5027991164 @default.
• W3021543552 hasAuthorship W3021543552A5033688106 @default.
• W3021543552 hasAuthorship W3021543552A5044089228 @default.
• W3021543552 hasAuthorship W3021543552A5054895333 @default.
• W3021543552 hasAuthorship W3021543552A5065192665 @default.
• W3021543552 hasAuthorship W3021543552A5066778872 @default.
• W3021543552 hasAuthorship W3021543552A5067797706 @default.
• W3021543552 hasAuthorship W3021543552A5073988415 @default.
• W3021543552 hasConcept C126322002 @default.
• W3021543552 hasConcept C164705383 @default.
• W3021543552 hasConcept C185592680 @default.
• W3021543552 hasConcept C203092338 @default.
• W3021543552 hasConcept C2775846464 @default.
• W3021543552 hasConcept C2775915353 @default.
• W3021543552 hasConcept C2775935837 @default.
• W3021543552 hasConcept C2776914184 @default.
• W3021543552 hasConcept C2777093960 @default.
• W3021543552 hasConcept C2778198053 @default.
• W3021543552 hasConcept C2778797674 @default.
• W3021543552 hasConcept C2781195455 @default.
• W3021543552 hasConcept C2781197716 @default.
• W3021543552 hasConcept C35785553 @default.
• W3021543552 hasConcept C535046627 @default.
• W3021543552 hasConcept C55493867 @default.
• W3021543552 hasConcept C71924100 @default.
• W3021543552 hasConcept C78085059 @default.
• W3021543552 hasConceptScore W3021543552C126322002 @default.
• W3021543552 hasConceptScore W3021543552C164705383 @default.
• W3021543552 hasConceptScore W3021543552C185592680 @default.
• W3021543552 hasConceptScore W3021543552C203092338 @default.
• W3021543552 hasConceptScore W3021543552C2775846464 @default.
• W3021543552 hasConceptScore W3021543552C2775915353 @default.
• W3021543552 hasConceptScore W3021543552C2775935837 @default.
• W3021543552 hasConceptScore W3021543552C2776914184 @default.
• W3021543552 hasConceptScore W3021543552C2777093960 @default.
• W3021543552 hasConceptScore W3021543552C2778198053 @default.
• W3021543552 hasConceptScore W3021543552C2778797674 @default.
• W3021543552 hasConceptScore W3021543552C2781195455 @default.
• W3021543552 hasConceptScore W3021543552C2781197716 @default.
• W3021543552 hasConceptScore W3021543552C35785553 @default.
• W3021543552 hasConceptScore W3021543552C535046627 @default.
• W3021543552 hasConceptScore W3021543552C55493867 @default.
• W3021543552 hasConceptScore W3021543552C71924100 @default.
• W3021543552 hasConceptScore W3021543552C78085059 @default.
• W3021543552 hasFunder F4320310567 @default.
• W3021543552 hasLocation W30215435521 @default.
• W3021543552 hasOpenAccess W3021543552 @default.
• W3021543552 hasPrimaryLocation W30215435521 @default.
• W3021543552 hasRelatedWork W11138576 @default.
• W3021543552 hasRelatedWork W11304534 @default.
• W3021543552 hasRelatedWork W14519780 @default.
• W3021543552 hasRelatedWork W14674810 @default.
• W3021543552 hasRelatedWork W17020087 @default.
• W3021543552 hasRelatedWork W19231002 @default.
• W3021543552 hasRelatedWork W400556 @default.
• W3021543552 hasRelatedWork W6111848 @default.
• W3021543552 hasRelatedWork W9482636 @default.
• W3021543552 hasRelatedWork W10250674 @default.
• W3021543552 isParatext "false" @default.
• W3021543552 isRetracted "false" @default.
• W3021543552 magId "3021543552" @default.

• next