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• W3021580558 abstract "You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD25)1 Apr 2020PD25-06 MEN WITH PREVIOUS CANCER DIAGNOSIS HAVE LOWER PARITY: A CASE-CONTROL ANALYSIS OF THE UTAH POPULATION DATABASE Kelli Gross*, Huong Meeks, Deepika Garg, Darshan Patel, Alexander Pastuszak, Heidi Hanson, Ken Smith, Joseph Letourneau, and James Hotaling Kelli Gross*Kelli Gross* More articles by this author , Huong MeeksHuong Meeks More articles by this author , Deepika GargDeepika Garg More articles by this author , Darshan PatelDarshan Patel More articles by this author , Alexander PastuszakAlexander Pastuszak More articles by this author , Heidi HansonHeidi Hanson More articles by this author , Ken SmithKen Smith More articles by this author , Joseph LetourneauJoseph Letourneau More articles by this author , and James HotalingJames Hotaling More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000882.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The long-term effects of cancer and cancer treatments on male reproduction over the lifetime have been incompletely elucidated. We hypothesize that men with cancer have lower parity compared to men who were never diagnosed with cancer. METHODS: We performed a retrospective matched case-control study using the Utah Population Database to compare parity of male cancer patients to their matching controls. We identified 21,389 male cancer patients diagnosed from 1956 to 2013 who resided in Utah at the time of cancer diagnosis. After excluding men with cancer diagnosis prior to 18 years of age and those without matching controls, a total of 19,599 male cancer patients were included in the analysis. Patients were matched with controls with no cancer diagnoses in a 5:1 ratio by birth year, born in/out of Utah and time residing in Utah. A total of 95,143 men were included as control subjects. Live births in Utah were reported and compared between groups. The estimated effect of being diagnosed with cancer on parity after first cancer diagnosis was compared using conditional Poisson regression models, adjusting for race, ethnicity and number of live births prior to first cancer diagnosis. RESULTS: Cancer cases were significantly more likely to be Caucasian (95.0% vs 88.7% for controls, p<0.001) and non-Hispanic (89.8% vs 73.0% for controls, p<0.001). With regards to cancer stage, 19.5% of men had metastatic disease, 18.3% had regional disease, 49.7% had localized disease, and 6.9% had carcinoma in situ. Cancer cases had 25% lower parity compared to their matched controls (IRR = 0.75; 95% CI = 0.73-0.76; p < 0.001). A statistically significant effect was seen in across all cancer types (Table 1). With all cancer types combined, statistical significance was seen across all age groups evaluated, specifically ages 18-30 (IRR = 0.71; 95% CI = 0.68-0.75; p < 0.001), 31-40 (IRR = 0.83; 95% CI = 0.78-0.88; p < 0.001), 41-54 (IRR = 0.61; 95% CI = 0.58-0.64; p < 0.001), and ≥55 (IRR = 0.29; 95% CI = 0.24-0.36; p < 0.001). CONCLUSIONS: Men who have cancer have significantly lower parity compared to age matched controls regardless of age of first cancer diagnosis or cancer type. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e540-e540 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kelli Gross* More articles by this author Huong Meeks More articles by this author Deepika Garg More articles by this author Darshan Patel More articles by this author Alexander Pastuszak More articles by this author Heidi Hanson More articles by this author Ken Smith More articles by this author Joseph Letourneau More articles by this author James Hotaling More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W3021580558 title "PD25-06 MEN WITH PREVIOUS CANCER DIAGNOSIS HAVE LOWER PARITY: A CASE-CONTROL ANALYSIS OF THE UTAH POPULATION DATABASE" @default.
• W3021580558 doi "https://doi.org/10.1097/ju.0000000000000882.06" @default.
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