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- W3021613507 abstract "Significance Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and is a leading cause of death in these patients. It is an orphan disease with no specific treatment. In this study, we investigated the mechanisms of NEC-related thrombocytopenia, a characteristic feature of this disease. We tested the hypothesis that platelet activation and depletion occur during NEC once mucosal disruption is well established and is secondary to bacterial translocation across the damaged mucosa. Surprisingly, platelet activation turned out to be an early thrombin-mediated pathogenetic event during NEC-like injury. We show that a targeted nanomedicine approach to inhibit thrombin can attenuate NEC-like injury. If confirmed in clinical studies, this would be a specific treatment for NEC." @default.
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- W3021613507 date "2020-05-04" @default.
- W3021613507 modified "2023-10-15" @default.
- W3021613507 title "Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis" @default.
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- W3021613507 doi "https://doi.org/10.1073/pnas.1912357117" @default.
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