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- W3021645836 endingPage "1133" @default.
- W3021645836 startingPage "1133" @default.
- W3021645836 abstract "Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma have been identified. They all form heterodimers with retinoic X receptors to activate or repress downstream target genes dependent on the presence/absence of ligands and coactivators or corepressors. PPARs differ in their tissue expression profile, ligands and specific agonists and antagonists. PPARs attract attention as potential therapeutic targets for a variety of diseases. PPAR alpha and gamma agonists are in clinical use for the treatment of dyslipidemias and diabetes. For both receptors, several clinical trials as potential therapeutic targets for cancer are ongoing. In contrast, PPAR beta/delta has been suggested as a therapeutic target for metabolic syndrome. However, potential risks in the settings of cancer are less clear. A variety of studies have investigated PPAR beta/delta expression or activation/inhibition in different cancer cell models in vitro, but the relevance for cancer growth in vivo is less well documented and controversial. In this review, we summarize critically the knowledge of PPAR beta/delta functions for the different hallmarks of cancer biological capabilities, which interplay to determine cancer growth." @default.
- W3021645836 created "2020-05-13" @default.
- W3021645836 creator A5069245717 @default.
- W3021645836 creator A5073673633 @default.
- W3021645836 date "2020-05-04" @default.
- W3021645836 modified "2023-10-16" @default.
- W3021645836 title "PPAR Beta/Delta and the Hallmarks of Cancer" @default.
- W3021645836 cites W1490298078 @default.
- W3021645836 cites W1492626232 @default.
- W3021645836 cites W1526570055 @default.
- W3021645836 cites W1557991089 @default.
- W3021645836 cites W1561814525 @default.
- W3021645836 cites W1863367863 @default.
- W3021645836 cites W1906315241 @default.
- W3021645836 cites W1923214121 @default.
- W3021645836 cites W1947281025 @default.
- W3021645836 cites W1965533994 @default.
- W3021645836 cites W1967679232 @default.
- W3021645836 cites W1968752758 @default.
- W3021645836 cites W1968845100 @default.
- W3021645836 cites W1973312372 @default.
- W3021645836 cites W1975012443 @default.
- W3021645836 cites W1978311357 @default.
- W3021645836 cites W1979201752 @default.
- W3021645836 cites W1979356105 @default.
- W3021645836 cites W1981723630 @default.
- W3021645836 cites W1982075308 @default.
- W3021645836 cites W1982223049 @default.
- W3021645836 cites W1983321881 @default.
- W3021645836 cites W1989934461 @default.
- W3021645836 cites W1993728889 @default.
- W3021645836 cites W1994049242 @default.
- W3021645836 cites W1995161424 @default.
- W3021645836 cites W1997433818 @default.
- W3021645836 cites W2006340844 @default.
- W3021645836 cites W2006574739 @default.
- W3021645836 cites W2007239438 @default.
- W3021645836 cites W2008539465 @default.
- W3021645836 cites W2008589779 @default.
- W3021645836 cites W2009173078 @default.
- W3021645836 cites W2010788519 @default.
- W3021645836 cites W2012834939 @default.
- W3021645836 cites W2013692456 @default.
- W3021645836 cites W2014058353 @default.
- W3021645836 cites W2014277844 @default.
- W3021645836 cites W2014350033 @default.
- W3021645836 cites W2015743729 @default.
- W3021645836 cites W2016264364 @default.
- W3021645836 cites W2017265065 @default.
- W3021645836 cites W2017671227 @default.
- W3021645836 cites W2020747769 @default.
- W3021645836 cites W2022067890 @default.
- W3021645836 cites W2023459898 @default.
- W3021645836 cites W2028186105 @default.
- W3021645836 cites W2029181833 @default.
- W3021645836 cites W2030130710 @default.
- W3021645836 cites W2031581878 @default.
- W3021645836 cites W2034269086 @default.
- W3021645836 cites W2034822725 @default.
- W3021645836 cites W2035904563 @default.
- W3021645836 cites W2036470685 @default.
- W3021645836 cites W2037867055 @default.
- W3021645836 cites W2038654926 @default.
- W3021645836 cites W2040134719 @default.
- W3021645836 cites W2042916681 @default.
- W3021645836 cites W2045744255 @default.
- W3021645836 cites W2046468798 @default.
- W3021645836 cites W2046935888 @default.
- W3021645836 cites W2046951491 @default.
- W3021645836 cites W2050409528 @default.
- W3021645836 cites W2051665354 @default.
- W3021645836 cites W2053242629 @default.
- W3021645836 cites W2053675903 @default.
- W3021645836 cites W2056352736 @default.
- W3021645836 cites W2057294527 @default.
- W3021645836 cites W2060116460 @default.
- W3021645836 cites W2061075485 @default.
- W3021645836 cites W2062159267 @default.
- W3021645836 cites W2063125770 @default.
- W3021645836 cites W2063153846 @default.
- W3021645836 cites W2065133286 @default.
- W3021645836 cites W2065725049 @default.
- W3021645836 cites W2068231503 @default.
- W3021645836 cites W2070909262 @default.
- W3021645836 cites W2072451938 @default.
- W3021645836 cites W2072744580 @default.
- W3021645836 cites W2072823779 @default.
- W3021645836 cites W2072839085 @default.
- W3021645836 cites W2072939418 @default.
- W3021645836 cites W2076973370 @default.
- W3021645836 cites W2077688090 @default.
- W3021645836 cites W2081555916 @default.
- W3021645836 cites W2081924229 @default.
- W3021645836 cites W2084761705 @default.
- W3021645836 cites W2085589895 @default.
- W3021645836 cites W2091511314 @default.
- W3021645836 cites W2092001735 @default.
- W3021645836 cites W2093594164 @default.