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- W3021668671 abstract "Introduction and objectives COPD is associated with significant morbidity and mortality. Home non-invasive ventilation (NIV) is thought to offer some benefit to patients in chronic ventilatory failure, although its use remains controversial.1 The primary outcome of this study is to evaluate exacerbation frequency requiring hospitalisation following initiation of domiciliary NIV. Method This is a retrospective study of COPD patients receiving domiciliary NIV in Wessex. Data were collected from patients’ notes and available electronic databases. Comparison between groups was assessed by Student’s T-Test. Results 59 patients were identified with an average age of 64 years (range 42–83). 42% had co-existing diagnoses e.g. obstructive sleep apnoea (OSA) or obesity hypoventilation syndrome (OHS). Patients had severe COPD (FEV1 of 30% predicted). 32 patients (54%) started NIV as an inpatient. NIV usage on average was optimal with a minimum of 7.68 hours per night. Following the initiation of domiciliary NIV, there were improvements in arterial pH, PaCO2 and oxygenation. There was a 45% relative risk reduction in COPD related hospitalisations at 24 months following the initiation of domiciliary NIV (p=0.0006). Conclusion Our data show a significant reduction in the frequency of COPD related hospitalisations post initiation of domiciliary NIV. These results are consistent with the findings from a recent randomised control trial.2 Ongoing data collection is required to assess the impact of this intervention on long term mortality. References Dretzke J, et al. International Journal of COPD2016;11:2269–86. Murphy PB, et al. JAMA2017;317:2177–218." @default.
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- W3021668671 date "2018-12-01" @default.
- W3021668671 modified "2023-09-26" @default.
- W3021668671 title "P204 A retrospective study of home non-invasive ventilation for patients with severe COPD in a regional centre" @default.
- W3021668671 doi "https://doi.org/10.1136/thorax-2018-212555.361" @default.
- W3021668671 hasPublicationYear "2018" @default.
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