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• W3021672024 abstract "BackgroundTo date, sparse data exists on the safety margins we should include for benign meningiomas treated with fractionated stereotactic radiotherapy (FSRT).Purpose/Objective(s)The purpose of this study was to investigate intra-observer and inter-observer variability in contouring benign meningiomas in order to select an appropriate margin.Materials/MethodsTwelve consecutive patients who had undergone FSRT for benign intracranial meningiomas were studied. Two radiation oncologists and one neuroradiologist independently contoured the target volume on two occasions, separated by at least a one week interval, on merged MRI and CT-scan. The stereotactic planning system used was Brainscan, version 5.31, BrainLAB AG. Absolute and relative variability in intra-observer volume measurements were calculated. Concerning inter-observer variability, we analyzed the mean absolute difference between volumes as well as the absolute positional shift in three dimensions.ResultsThe mean intra-observer variability was 5.2% (0.56cc) with a maximum of 12.97% (0.59cc). For inter-observer measurements, the mean maximal difference was 2.13cc with a maximum of 7.14cc. The average standard deviation (SD) for all volumes was ±0.84cc. The mean absolute positional shift was 1.03mm (±0.44mm SD) with a maximum of 2.79mm.ConclusionsOptimal radiotherapy planning relies on accurate delimitation of tumor volumes in order to spare critical structures and normal tissue. These results demonstrate that intra-observer variability does not seem to be significant. Inter-observer volume determination is more variable. However, the absolute positional shift is of small magnitude. We conclude that the application of a 2mm margin on the target volume seems safe in order to cover 95% (two SD) of the inter-observer variability. BackgroundTo date, sparse data exists on the safety margins we should include for benign meningiomas treated with fractionated stereotactic radiotherapy (FSRT). To date, sparse data exists on the safety margins we should include for benign meningiomas treated with fractionated stereotactic radiotherapy (FSRT). Purpose/Objective(s)The purpose of this study was to investigate intra-observer and inter-observer variability in contouring benign meningiomas in order to select an appropriate margin. The purpose of this study was to investigate intra-observer and inter-observer variability in contouring benign meningiomas in order to select an appropriate margin. Materials/MethodsTwelve consecutive patients who had undergone FSRT for benign intracranial meningiomas were studied. Two radiation oncologists and one neuroradiologist independently contoured the target volume on two occasions, separated by at least a one week interval, on merged MRI and CT-scan. The stereotactic planning system used was Brainscan, version 5.31, BrainLAB AG. Absolute and relative variability in intra-observer volume measurements were calculated. Concerning inter-observer variability, we analyzed the mean absolute difference between volumes as well as the absolute positional shift in three dimensions. Twelve consecutive patients who had undergone FSRT for benign intracranial meningiomas were studied. Two radiation oncologists and one neuroradiologist independently contoured the target volume on two occasions, separated by at least a one week interval, on merged MRI and CT-scan. The stereotactic planning system used was Brainscan, version 5.31, BrainLAB AG. Absolute and relative variability in intra-observer volume measurements were calculated. Concerning inter-observer variability, we analyzed the mean absolute difference between volumes as well as the absolute positional shift in three dimensions. ResultsThe mean intra-observer variability was 5.2% (0.56cc) with a maximum of 12.97% (0.59cc). For inter-observer measurements, the mean maximal difference was 2.13cc with a maximum of 7.14cc. The average standard deviation (SD) for all volumes was ±0.84cc. The mean absolute positional shift was 1.03mm (±0.44mm SD) with a maximum of 2.79mm. The mean intra-observer variability was 5.2% (0.56cc) with a maximum of 12.97% (0.59cc). For inter-observer measurements, the mean maximal difference was 2.13cc with a maximum of 7.14cc. The average standard deviation (SD) for all volumes was ±0.84cc. The mean absolute positional shift was 1.03mm (±0.44mm SD) with a maximum of 2.79mm. ConclusionsOptimal radiotherapy planning relies on accurate delimitation of tumor volumes in order to spare critical structures and normal tissue. These results demonstrate that intra-observer variability does not seem to be significant. Inter-observer volume determination is more variable. However, the absolute positional shift is of small magnitude. We conclude that the application of a 2mm margin on the target volume seems safe in order to cover 95% (two SD) of the inter-observer variability. Optimal radiotherapy planning relies on accurate delimitation of tumor volumes in order to spare critical structures and normal tissue. These results demonstrate that intra-observer variability does not seem to be significant. Inter-observer volume determination is more variable. However, the absolute positional shift is of small magnitude. We conclude that the application of a 2mm margin on the target volume seems safe in order to cover 95% (two SD) of the inter-observer variability." @default.
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• W3021672024 date "2006-11-01" @default.
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• W3021672024 doi "https://doi.org/10.1016/j.ijrobp.2006.07.482" @default.
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