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- W3021687013 abstract "This chapter discusses the production of potentially important antineoplastic agent tripdiolide in tissue cultures of Tripterygium wilfordii.Tripdiolide and triptolide reveal significant activity in vivo against L-1210 and P-388 leukemias in the mouse and in vitro against cells derived from human carcinoma of the nasopharynx. The chapter further discusses the development of satisfactory growth conditions, optimization of growth parameters for the production of the target compound tripdiolide, and detailed chemical analyses of the cell-produced secondary metabolites in addition to the target compounds. To ascertain the levels of tripdiolide in both the callus and cell suspension cultures, a method involving thin layer chromatography assay and fluorimetric detection is used. The chapter also examines the influence of medium composition on tripdiolide production. To derive additional information about the biosynthesis and/or cell production of tripdiolide, a number of biotransformation experiments has been considered. Such experiments involve substrates possessing the diterpene system at a lower oxidation level, which can be derived by chemical conversions of the dehydroabietic acid." @default.
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- W3021687013 date "1988-01-01" @default.
- W3021687013 modified "2023-09-26" @default.
- W3021687013 title "Diterpenes" @default.
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- W3021687013 doi "https://doi.org/10.1016/b978-0-12-715005-5.50016-9" @default.
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