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• W3021688823 abstract "Abstract The site of SARS-CoV-2 entry and replication critically impacts strategies for COVID-19 diagnosis, transmission mitigation, and treatment. We determined the cellular location of the SARS-CoV-2 target receptor protein, ACE2, in the human upper airway, finding striking enrichment (200-700 folds) in the olfactory neuroepithelium relative to nasal respiratory or tracheal epithelial cells. This cellular tropism of SARS-CoV-2 may underlie its high transmissibility and association with olfactory dysfunction, while suggesting a viral reservoir potentially amenable to intranasal therapy." @default.
• W3021688823 created "2020-05-13" @default.
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• W3021688823 date "2020-05-09" @default.
• W3021688823 modified "2023-10-13" @default.
• W3021688823 title "Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication" @default.
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• W3021688823 doi "https://doi.org/10.1101/2020.05.08.084996" @default.
• W3021688823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7263519" @default.
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