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- W3021693834 abstract "Introduction The relationship between symptomatology, serology and findings on small bowel capsule endoscopy (SBCE) in patients with coeliac disease (CD) remains unclear. Clarifying such associations will help determine if symptoms and serology can predict severity and extent of disease on SBCE. Methods Patients with newly diagnosed CD (villous atrophy on duodenal histology and positive CD serology) were recruited. Patients underwent a SBCE at the time of diagnosis. Information on SBCE was recorded. Signs and symptoms at presentation, serological markers, histological classification of disease in the duodenum were noted. Results Sixty patients with newly diagnosed CD (mean age 44.9 years SD±17.4, 17 - 76) were included in this study. Older patients (p=0.025) and patients presenting with iron deficiency anaemia had more extensive small bowel (SB) involvement (p=0.026). Patients presenting with weight loss were more likely to have SB involvement beyond the duodenum (p=0.027). Patients presenting with iron deficiency anaemia (p=0.038) and weight loss (p=0.009) were significantly older at diagnosis. Serum albumin was lower in those patients diagnosed later on in life (p=0.007). There was no significant association between anti-tissue transglutaminase antibody (p=0.396) and extent of affected SB mucosa. Patients with more severe Marsh classification of disease on histology from the duodenal bulb had more extensive SB involvement (p=0.017). Conclusions This is the largest study on newly diagnosed CD and SBCE. Older patients are likely to have more extensive disease on SBCE at diagnosis. Symptoms and serology had no impact on the findings on SBCE apart from weight loss and iron deficiency anaemia. Reference Lau M, Mooney P, White W, et al. PWE-058 The Role of A Point of Care Test, Simtomax, in Predicting Histological Remission in Coeliac Disease on A Gluten Free Diet. Gut 2016;65:A166–A167." @default.
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- W3021693834 date "2019-06-01" @default.
- W3021693834 modified "2023-10-12" @default.
- W3021693834 title "PWE-023 Coeliac disease – older patients have the most extensive small bowel involvement on capsule endoscopy" @default.
- W3021693834 doi "https://doi.org/10.1136/gutjnl-2019-bsgabstracts.311" @default.
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