FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021728774> ?p ?o ?g. }

• W3021728774 endingPage "61" @default.
• W3021728774 startingPage "57" @default.
• W3021728774 abstract "Autism spectrum disorders (ASD) are influenced by interacting maternal and environmental risk factors. High-dose folinic acid has shown improvement in verbal communication in ASD children. The EFFET randomized placebo-controlled trial (NCT02551380) aimed to evaluate the efficacy of folinic acid (FOLINORAL®) at a lower dose of 5 mg twice daily. Nineteen children were included in the EFFET trial. The primary efficacy outcome was improvement of Autism Diagnostic Observation Schedule (ADOS) score. The secondary outcomes were the improvement in ADOS sub scores communication, social interactions, Social Responsiveness Score (SRS) and treatment safety. The global ADOS score and social interaction and communication sub scores were significantly improved at week 12 compared to baseline in the folinic acid group (P = 0.003, P = 0.004 and P = 0.022, respectively), but not in the placebo group (P = 0.574, P = 0.780, P = 0.269, respectively). We observed a greater change of ADOS global score (−2.78 vs. −0.4 points) and (−1.78 vs. 0.20 points) in the folinic acid group, compared to the placebo group. No serious adverse events were observed. This pilot study showed significant efficacy of folinic acid with an oral formulation that is readily available. It opens a perspective of therapeutic intervention with folinic acid but needs to be confirmed by a multi-center trial on a larger number of children." @default.
• W3021728774 created "2020-05-13" @default.
• W3021728774 creator A5033155748 @default.
• W3021728774 creator A5039458198 @default.
• W3021728774 creator A5069815569 @default.
• W3021728774 creator A5075162828 @default.
• W3021728774 creator A5075482832 @default.
• W3021728774 creator A5090435464 @default.
• W3021728774 date "2020-06-01" @default.
• W3021728774 modified "2023-10-18" @default.
• W3021728774 title "Folinic acid improves the score of Autism in the EFFET placebo-controlled randomized trial" @default.
• W3021728774 cites W1588132147 @default.
• W3021728774 cites W1975717285 @default.
• W3021728774 cites W2016386954 @default.
• W3021728774 cites W2108435240 @default.
• W3021728774 cites W2113172416 @default.
• W3021728774 cites W2129516277 @default.
• W3021728774 cites W2135272972 @default.
• W3021728774 cites W2136019630 @default.
• W3021728774 cites W2149197787 @default.
• W3021728774 cites W2156287076 @default.
• W3021728774 cites W2170412346 @default.
• W3021728774 cites W2331292814 @default.
• W3021728774 cites W2343000142 @default.
• W3021728774 cites W2536387587 @default.
• W3021728774 cites W2736709477 @default.
• W3021728774 cites W2761279675 @default.
• W3021728774 cites W2767663386 @default.
• W3021728774 cites W2789615748 @default.
• W3021728774 cites W2883210979 @default.
• W3021728774 cites W2900459804 @default.
• W3021728774 doi "https://doi.org/10.1016/j.biochi.2020.04.019" @default.
• W3021728774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32387472" @default.
• W3021728774 hasPublicationYear "2020" @default.
• W3021728774 type Work @default.
• W3021728774 sameAs 3021728774 @default.
• W3021728774 citedByCount "12" @default.
• W3021728774 countsByYear W30217287742020 @default.
• W3021728774 countsByYear W30217287742021 @default.
• W3021728774 countsByYear W30217287742022 @default.
• W3021728774 countsByYear W30217287742023 @default.
• W3021728774 crossrefType "journal-article" @default.
• W3021728774 hasAuthorship W3021728774A5033155748 @default.
• W3021728774 hasAuthorship W3021728774A5039458198 @default.
• W3021728774 hasAuthorship W3021728774A5069815569 @default.
• W3021728774 hasAuthorship W3021728774A5075162828 @default.
• W3021728774 hasAuthorship W3021728774A5075482832 @default.
• W3021728774 hasAuthorship W3021728774A5090435464 @default.
• W3021728774 hasBestOaLocation W30217287741 @default.
• W3021728774 hasConcept C118552586 @default.
• W3021728774 hasConcept C126322002 @default.
• W3021728774 hasConcept C142724271 @default.
• W3021728774 hasConcept C168563851 @default.
• W3021728774 hasConcept C197934379 @default.
• W3021728774 hasConcept C204787440 @default.
• W3021728774 hasConcept C205778803 @default.
• W3021728774 hasConcept C27081682 @default.
• W3021728774 hasConcept C2776694085 @default.
• W3021728774 hasConcept C2778538070 @default.
• W3021728774 hasConcept C2779804826 @default.
• W3021728774 hasConcept C2780055620 @default.
• W3021728774 hasConcept C2780456651 @default.
• W3021728774 hasConcept C535046627 @default.
• W3021728774 hasConcept C71924100 @default.
• W3021728774 hasConceptScore W3021728774C118552586 @default.
• W3021728774 hasConceptScore W3021728774C126322002 @default.
• W3021728774 hasConceptScore W3021728774C142724271 @default.
• W3021728774 hasConceptScore W3021728774C168563851 @default.
• W3021728774 hasConceptScore W3021728774C197934379 @default.
• W3021728774 hasConceptScore W3021728774C204787440 @default.
• W3021728774 hasConceptScore W3021728774C205778803 @default.
• W3021728774 hasConceptScore W3021728774C27081682 @default.
• W3021728774 hasConceptScore W3021728774C2776694085 @default.
• W3021728774 hasConceptScore W3021728774C2778538070 @default.
• W3021728774 hasConceptScore W3021728774C2779804826 @default.
• W3021728774 hasConceptScore W3021728774C2780055620 @default.
• W3021728774 hasConceptScore W3021728774C2780456651 @default.
• W3021728774 hasConceptScore W3021728774C535046627 @default.
• W3021728774 hasConceptScore W3021728774C71924100 @default.
• W3021728774 hasLocation W30217287741 @default.
• W3021728774 hasLocation W30217287742 @default.
• W3021728774 hasLocation W30217287743 @default.
• W3021728774 hasOpenAccess W3021728774 @default.
• W3021728774 hasPrimaryLocation W30217287741 @default.
• W3021728774 hasRelatedWork W2085830368 @default.
• W3021728774 hasRelatedWork W2290993951 @default.
• W3021728774 hasRelatedWork W2588314410 @default.
• W3021728774 hasRelatedWork W2759268857 @default.
• W3021728774 hasRelatedWork W2782379361 @default.
• W3021728774 hasRelatedWork W2883808992 @default.
• W3021728774 hasRelatedWork W2907813052 @default.
• W3021728774 hasRelatedWork W2983113363 @default.
• W3021728774 hasRelatedWork W3186235679 @default.
• W3021728774 hasRelatedWork W3192134007 @default.
• W3021728774 hasVolume "173" @default.
• W3021728774 isParatext "false" @default.
• W3021728774 isRetracted "false" @default.
• W3021728774 magId "3021728774" @default.

• next