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• W3021740767 startingPage "1912" @default.
• W3021740767 abstract "Background The connection between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is well-established, as persistent intestinal inflammation plays a substantial role in both disorders. Cytokines may further influence the inflammation and the carcinogenesis process. Aim To compare cytokine patterns of active IBD patients with early and advanced CRC. Methods Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior, in colon specimens, as mRNA biomarkers, and their serum protein levels. Results We found a significant difference between higher gene expression of FoxP3, TGFb1, IL-10, and IL-23, and approximately equal level of IL-6 in CRC patients in comparison with IBD patients. After stratification of CRC patients, we found a significant difference in FoxP3, IL-10, IL-23, and IL-17A mRNA in early cases compared to IBD, and IL-23 alone in advanced CRC. The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients. Conclusion Our findings showed that IL-6 upregulation is essential for both IBD and CRC development until the upregulation of other Th17/Treg related genes (TGFb1, IL-10, IL-23, and transcription factor FoxP3) is a crucial primarily for CRC development. The significantly upregulated IL-6 could be a potential drug target for IBD and prevention of CRC development as well." @default.
• W3021740767 created "2020-05-13" @default.
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• W3021740767 date "2020-04-28" @default.
• W3021740767 modified "2023-10-10" @default.
• W3021740767 title "Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer" @default.
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• W3021740767 doi "https://doi.org/10.3748/wjg.v26.i16.1912" @default.
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