FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021741331> ?p ?o ?g. }

• W3021741331 endingPage "481" @default.
• W3021741331 startingPage "481" @default.
• W3021741331 abstract "Based on their high clinical potential, the isolation and enrichment of rare circulating tumor cells (CTCs) from peripheral blood cells has been widely investigated. There have been technical challenges with CTC separation methods using solely cancer-specific surface molecules or just using physical properties of CTCs, as they may suffer from heterogeneity or lack of specificity from overlapping physical characteristics with leukocytes. Here, we integrated an immunomagnetic-based negative enrichment method that utilizes magnetic beads attached to leukocyte-specific surface antigens, with a physical separation method that utilizes the distinct size and deformability of CTCs. By manipulating the pressure distribution throughout the device and balancing the drag and magnetic forces acting on the magnetically labeled white blood cells (WBCs), the sequential physical and magnetophoretic separations were optimized to isolate intact cancer cells, regardless of heterogeneity from whole blood. Using a breast cancer cell line in whole blood, we achieved 100% separation efficiency for cancer cells and an average of 97.2% for WBCs, which resulted in a 93.3% average separation purity. The experimental results demonstrated that our microfluidic device can be a promising candidate for liquid biopsy and can be a vital tool for aiding future cancer research." @default.
• W3021741331 created "2020-05-13" @default.
• W3021741331 creator A5002443178 @default.
• W3021741331 creator A5052166840 @default.
• W3021741331 creator A5073219625 @default.
• W3021741331 date "2020-05-06" @default.
• W3021741331 modified "2023-10-18" @default.
• W3021741331 title "Enrichment of Circulating Tumor Cells from Whole Blood Using a Microfluidic Device for Sequential Physical and Magnetophoretic Separations" @default.
• W3021741331 cites W1964081206 @default.
• W3021741331 cites W1984736273 @default.
• W3021741331 cites W2028843745 @default.
• W3021741331 cites W2030994952 @default.
• W3021741331 cites W2038841741 @default.
• W3021741331 cites W2042198997 @default.
• W3021741331 cites W2042799308 @default.
• W3021741331 cites W2050547995 @default.
• W3021741331 cites W2053961194 @default.
• W3021741331 cites W2056777828 @default.
• W3021741331 cites W2057306577 @default.
• W3021741331 cites W2068108051 @default.
• W3021741331 cites W2071252006 @default.
• W3021741331 cites W2095192232 @default.
• W3021741331 cites W2111976640 @default.
• W3021741331 cites W2114624491 @default.
• W3021741331 cites W2114952348 @default.
• W3021741331 cites W2119764457 @default.
• W3021741331 cites W2120464557 @default.
• W3021741331 cites W2128117910 @default.
• W3021741331 cites W2147244189 @default.
• W3021741331 cites W2149414866 @default.
• W3021741331 cites W2159703296 @default.
• W3021741331 cites W2160650871 @default.
• W3021741331 cites W2161661776 @default.
• W3021741331 cites W2166779888 @default.
• W3021741331 cites W2169663475 @default.
• W3021741331 cites W2214066357 @default.
• W3021741331 cites W2604598570 @default.
• W3021741331 cites W2731680766 @default.
• W3021741331 cites W2913658713 @default.
• W3021741331 doi "https://doi.org/10.3390/mi11050481" @default.
• W3021741331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7281227" @default.
• W3021741331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32384825" @default.
• W3021741331 hasPublicationYear "2020" @default.
• W3021741331 type Work @default.
• W3021741331 sameAs 3021741331 @default.
• W3021741331 citedByCount "14" @default.
• W3021741331 countsByYear W30217413312020 @default.
• W3021741331 countsByYear W30217413312021 @default.
• W3021741331 countsByYear W30217413312022 @default.
• W3021741331 countsByYear W30217413312023 @default.
• W3021741331 crossrefType "journal-article" @default.
• W3021741331 hasAuthorship W3021741331A5002443178 @default.
• W3021741331 hasAuthorship W3021741331A5052166840 @default.
• W3021741331 hasAuthorship W3021741331A5073219625 @default.
• W3021741331 hasBestOaLocation W30217413311 @default.
• W3021741331 hasConcept C121608353 @default.
• W3021741331 hasConcept C136229726 @default.
• W3021741331 hasConcept C1621761 @default.
• W3021741331 hasConcept C171250308 @default.
• W3021741331 hasConcept C185592680 @default.
• W3021741331 hasConcept C191897082 @default.
• W3021741331 hasConcept C192562407 @default.
• W3021741331 hasConcept C203014093 @default.
• W3021741331 hasConcept C2779013556 @default.
• W3021741331 hasConcept C2779529041 @default.
• W3021741331 hasConcept C2779833257 @default.
• W3021741331 hasConcept C2781053203 @default.
• W3021741331 hasConcept C43617362 @default.
• W3021741331 hasConcept C54355233 @default.
• W3021741331 hasConcept C61238886 @default.
• W3021741331 hasConcept C71924100 @default.
• W3021741331 hasConcept C8673954 @default.
• W3021741331 hasConcept C86803240 @default.
• W3021741331 hasConcept C96232424 @default.
• W3021741331 hasConceptScore W3021741331C121608353 @default.
• W3021741331 hasConceptScore W3021741331C136229726 @default.
• W3021741331 hasConceptScore W3021741331C1621761 @default.
• W3021741331 hasConceptScore W3021741331C171250308 @default.
• W3021741331 hasConceptScore W3021741331C185592680 @default.
• W3021741331 hasConceptScore W3021741331C191897082 @default.
• W3021741331 hasConceptScore W3021741331C192562407 @default.
• W3021741331 hasConceptScore W3021741331C203014093 @default.
• W3021741331 hasConceptScore W3021741331C2779013556 @default.
• W3021741331 hasConceptScore W3021741331C2779529041 @default.
• W3021741331 hasConceptScore W3021741331C2779833257 @default.
• W3021741331 hasConceptScore W3021741331C2781053203 @default.
• W3021741331 hasConceptScore W3021741331C43617362 @default.
• W3021741331 hasConceptScore W3021741331C54355233 @default.
• W3021741331 hasConceptScore W3021741331C61238886 @default.
• W3021741331 hasConceptScore W3021741331C71924100 @default.
• W3021741331 hasConceptScore W3021741331C8673954 @default.
• W3021741331 hasConceptScore W3021741331C86803240 @default.
• W3021741331 hasConceptScore W3021741331C96232424 @default.
• W3021741331 hasFunder F4320322030 @default.
• W3021741331 hasFunder F4320322349 @default.
• W3021741331 hasIssue "5" @default.
• W3021741331 hasLocation W30217413311 @default.
• W3021741331 hasLocation W30217413312 @default.

• next