Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021751700> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3021751700 abstract "PET studies demonstrated reduced regional cerebral glucose metabolic rate (CMRGlc) and reduced cortical activity of acetylcholine esterase (AChE) as indicators of functional impairment in Alzheimer's disease (AD). The E4 allel of apolipoprotein ϵ (ApoE4) is a major risk factor for AD but its interaction with cholinergic degeneration is unclear. To examine the relation between ApoE genotype and cholinergic impairment in AD. We included 36 patients (mean age 66 years, 23 female, 13 male) with mild to moderate AD according to NINCDS–ADRDA criteria. 15 of them did not carry the ApoE4 allele, 15 were heterozygote, and 6 were homozygote ApoE4 carriers. Cortical AChE activity was studied by the acetylcholine analogue 11C–MP4A PET in 19 of these patients (11 ApoE4 positive, 8 negative). CMRGlc was measured by FDG PET in 35 patients (21 ApoE4 positive, 14 negative). Parametric images of AChE hydrolysis rate constant k3 were generated using a non–invasive technique with a putaminal reference region. Regional changes of CMRGlc were analysed by SPM2. The mean cortical k3 value of the ApoE4 positive subjects (2 homozygotes, 9 heterozygotes) was 0.0459 ± 0.0051 min–1, which was significantly higher (p < 0.05, t–test) than in ApoE4 negative subjects (n=8, 0.0399 ± 0.0066 min–1). Both groups were comparable with regard to age (63 vs. 65 years) and dementia severity (MMSE 20 vs. 22). In ApoE4 positive patients CMRGlc was reduced mostly in posterior cingulate and temporoparietal cortex, but more in frontal association cortex in the ApoE4 negative group. These results indicate that ApoE4 has no negative effect on AChE activity, suggesting that it does not impair its expression at cholinergic axons and synapses in cerebral cortex. Thus, ApoE4 appears to induce the risk for AD and associated functional impairment in temporoparietal association cortex by pathophysiological mechanisms that are unrelated to degeneration of cholinergic axons." @default.
- W3021751700 created "2020-05-13" @default.
- W3021751700 creator A5005195038 @default.
- W3021751700 creator A5053220474 @default.
- W3021751700 creator A5053401725 @default.
- W3021751700 creator A5090453640 @default.
- W3021751700 date "2006-07-01" @default.
- W3021751700 modified "2023-09-27" @default.
- W3021751700 title "P1-198: Cortical acetylcholine esterase activity, glucose metabolism, and ApoE4-genotype in Alzheimer disease: A PET study" @default.
- W3021751700 doi "https://doi.org/10.1016/j.jalz.2006.05.573" @default.
- W3021751700 hasPublicationYear "2006" @default.
- W3021751700 type Work @default.
- W3021751700 sameAs 3021751700 @default.
- W3021751700 citedByCount "0" @default.
- W3021751700 crossrefType "journal-article" @default.
- W3021751700 hasAuthorship W3021751700A5005195038 @default.
- W3021751700 hasAuthorship W3021751700A5053220474 @default.
- W3021751700 hasAuthorship W3021751700A5053401725 @default.
- W3021751700 hasAuthorship W3021751700A5090453640 @default.
- W3021751700 hasBestOaLocation W30217517001 @default.
- W3021751700 hasConcept C104317684 @default.
- W3021751700 hasConcept C126322002 @default.
- W3021751700 hasConcept C126838900 @default.
- W3021751700 hasConcept C134018914 @default.
- W3021751700 hasConcept C143409427 @default.
- W3021751700 hasConcept C153471976 @default.
- W3021751700 hasConcept C15744967 @default.
- W3021751700 hasConcept C169760540 @default.
- W3021751700 hasConcept C180754005 @default.
- W3021751700 hasConcept C181199279 @default.
- W3021751700 hasConcept C22885893 @default.
- W3021751700 hasConcept C2777348757 @default.
- W3021751700 hasConcept C2778733324 @default.
- W3021751700 hasConcept C2778816929 @default.
- W3021751700 hasConcept C2779134260 @default.
- W3021751700 hasConcept C39313694 @default.
- W3021751700 hasConcept C54355233 @default.
- W3021751700 hasConcept C55493867 @default.
- W3021751700 hasConcept C57089818 @default.
- W3021751700 hasConcept C71924100 @default.
- W3021751700 hasConcept C86803240 @default.
- W3021751700 hasConceptScore W3021751700C104317684 @default.
- W3021751700 hasConceptScore W3021751700C126322002 @default.
- W3021751700 hasConceptScore W3021751700C126838900 @default.
- W3021751700 hasConceptScore W3021751700C134018914 @default.
- W3021751700 hasConceptScore W3021751700C143409427 @default.
- W3021751700 hasConceptScore W3021751700C153471976 @default.
- W3021751700 hasConceptScore W3021751700C15744967 @default.
- W3021751700 hasConceptScore W3021751700C169760540 @default.
- W3021751700 hasConceptScore W3021751700C180754005 @default.
- W3021751700 hasConceptScore W3021751700C181199279 @default.
- W3021751700 hasConceptScore W3021751700C22885893 @default.
- W3021751700 hasConceptScore W3021751700C2777348757 @default.
- W3021751700 hasConceptScore W3021751700C2778733324 @default.
- W3021751700 hasConceptScore W3021751700C2778816929 @default.
- W3021751700 hasConceptScore W3021751700C2779134260 @default.
- W3021751700 hasConceptScore W3021751700C39313694 @default.
- W3021751700 hasConceptScore W3021751700C54355233 @default.
- W3021751700 hasConceptScore W3021751700C55493867 @default.
- W3021751700 hasConceptScore W3021751700C57089818 @default.
- W3021751700 hasConceptScore W3021751700C71924100 @default.
- W3021751700 hasConceptScore W3021751700C86803240 @default.
- W3021751700 hasIssue "3S_Part_5" @default.
- W3021751700 hasLocation W30217517001 @default.
- W3021751700 hasOpenAccess W3021751700 @default.
- W3021751700 hasPrimaryLocation W30217517001 @default.
- W3021751700 hasRelatedWork W1969213707 @default.
- W3021751700 hasRelatedWork W1970053685 @default.
- W3021751700 hasRelatedWork W1982745715 @default.
- W3021751700 hasRelatedWork W2085001524 @default.
- W3021751700 hasRelatedWork W2128633263 @default.
- W3021751700 hasRelatedWork W2150522638 @default.
- W3021751700 hasRelatedWork W2160510592 @default.
- W3021751700 hasRelatedWork W2275976839 @default.
- W3021751700 hasRelatedWork W2748952813 @default.
- W3021751700 hasRelatedWork W3184638953 @default.
- W3021751700 hasVolume "2" @default.
- W3021751700 isParatext "false" @default.
- W3021751700 isRetracted "false" @default.
- W3021751700 magId "3021751700" @default.
- W3021751700 workType "article" @default.