FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021762060> ?p ?o ?g. }

• W3021762060 endingPage "35" @default.
• W3021762060 startingPage "30" @default.
• W3021762060 abstract "Introduction: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer and a serious disease leading to increased morbidity and high medical costs worldwide. Despite the high recurrence rate of BCCs, the current standard of care consists of regular skin check-ups, with no know therapy to prevent the recurrence. Vitamin D is a safe, affordable, and easily available supplement used for various diseases. There is evidence suggesting its potential use in preventing BCCs, with studies showing that it inhibits the Hedgehog (HH) signaling pathway, an important stimulator of carcinogenesis and the main pathway in BCC development. The objective of this study is to determine the effect of oral vitamin D supplementation on the prevention of BCC redevelopment.Methods: This study is a phase III, multicenter, randomized, placebo-controlled, triple-blinded, superiority trial with two parallel groups on 1:1 allocation of 1746 patients with a previous diagnosis of BCC. The patients will either receive 1000 IU of Vitamin D daily or placebo.  During the three-year follow-up period, patients will be undergoing skin check-ups every six months, with laboratorial tests annually. The primary endpoint will be the development of further BCC during 3 years after the initiation of vitamin D supplementation. The statistical analysis will be a time-to-event approach.Discussion:This is a triple-blinded, randomized, placebo-controlled trial for prevention of a highly prevalent condition. Vitamin D would be a simple solution to prevent the development of further basal cell carcinoma, having tremendous positive effect not only by improving the quality of life of patients, but also by reducing the financial burden on health care systems." @default.
• W3021762060 created "2020-05-13" @default.
• W3021762060 creator A5007606688 @default.
• W3021762060 creator A5008542795 @default.
• W3021762060 creator A5014104597 @default.
• W3021762060 creator A5016988898 @default.
• W3021762060 creator A5059520549 @default.
• W3021762060 creator A5066050353 @default.
• W3021762060 creator A5068868243 @default.
• W3021762060 creator A5069480076 @default.
• W3021762060 creator A5069814416 @default.
• W3021762060 creator A5071273012 @default.
• W3021762060 creator A5072246152 @default.
• W3021762060 creator A5072749016 @default.
• W3021762060 creator A5072847049 @default.
• W3021762060 creator A5073417100 @default.
• W3021762060 creator A5073776208 @default.
• W3021762060 creator A5074063304 @default.
• W3021762060 creator A5076063498 @default.
• W3021762060 creator A5078479245 @default.
• W3021762060 creator A5079522057 @default.
• W3021762060 creator A5079862989 @default.
• W3021762060 date "2019-07-05" @default.
• W3021762060 modified "2023-09-26" @default.
• W3021762060 title "Vitamin D Supplementation to Prevent Redevelopment of Basal Cell Carcinoma (BCC): A Phase III Randomized Clinical Trial Protocol" @default.
• W3021762060 cites W1529230314 @default.
• W3021762060 cites W1971941564 @default.
• W3021762060 cites W1998907255 @default.
• W3021762060 cites W2042825747 @default.
• W3021762060 cites W2127168458 @default.
• W3021762060 cites W2138530019 @default.
• W3021762060 cites W2140708417 @default.
• W3021762060 cites W2141453076 @default.
• W3021762060 hasPublicationYear "2019" @default.
• W3021762060 type Work @default.
• W3021762060 sameAs 3021762060 @default.
• W3021762060 citedByCount "0" @default.
• W3021762060 crossrefType "journal-article" @default.
• W3021762060 hasAuthorship W3021762060A5007606688 @default.
• W3021762060 hasAuthorship W3021762060A5008542795 @default.
• W3021762060 hasAuthorship W3021762060A5014104597 @default.
• W3021762060 hasAuthorship W3021762060A5016988898 @default.
• W3021762060 hasAuthorship W3021762060A5059520549 @default.
• W3021762060 hasAuthorship W3021762060A5066050353 @default.
• W3021762060 hasAuthorship W3021762060A5068868243 @default.
• W3021762060 hasAuthorship W3021762060A5069480076 @default.
• W3021762060 hasAuthorship W3021762060A5069814416 @default.
• W3021762060 hasAuthorship W3021762060A5071273012 @default.
• W3021762060 hasAuthorship W3021762060A5072246152 @default.
• W3021762060 hasAuthorship W3021762060A5072749016 @default.
• W3021762060 hasAuthorship W3021762060A5072847049 @default.
• W3021762060 hasAuthorship W3021762060A5073417100 @default.
• W3021762060 hasAuthorship W3021762060A5073776208 @default.
• W3021762060 hasAuthorship W3021762060A5074063304 @default.
• W3021762060 hasAuthorship W3021762060A5076063498 @default.
• W3021762060 hasAuthorship W3021762060A5078479245 @default.
• W3021762060 hasAuthorship W3021762060A5079522057 @default.
• W3021762060 hasAuthorship W3021762060A5079862989 @default.
• W3021762060 hasConcept C121608353 @default.
• W3021762060 hasConcept C126322002 @default.
• W3021762060 hasConcept C141071460 @default.
• W3021762060 hasConcept C142724271 @default.
• W3021762060 hasConcept C168563851 @default.
• W3021762060 hasConcept C203092338 @default.
• W3021762060 hasConcept C204787440 @default.
• W3021762060 hasConcept C27081682 @default.
• W3021762060 hasConcept C2777789703 @default.
• W3021762060 hasConcept C2778804307 @default.
• W3021762060 hasConcept C3019992690 @default.
• W3021762060 hasConcept C535046627 @default.
• W3021762060 hasConcept C71924100 @default.
• W3021762060 hasConceptScore W3021762060C121608353 @default.
• W3021762060 hasConceptScore W3021762060C126322002 @default.
• W3021762060 hasConceptScore W3021762060C141071460 @default.
• W3021762060 hasConceptScore W3021762060C142724271 @default.
• W3021762060 hasConceptScore W3021762060C168563851 @default.
• W3021762060 hasConceptScore W3021762060C203092338 @default.
• W3021762060 hasConceptScore W3021762060C204787440 @default.
• W3021762060 hasConceptScore W3021762060C27081682 @default.
• W3021762060 hasConceptScore W3021762060C2777789703 @default.
• W3021762060 hasConceptScore W3021762060C2778804307 @default.
• W3021762060 hasConceptScore W3021762060C3019992690 @default.
• W3021762060 hasConceptScore W3021762060C535046627 @default.
• W3021762060 hasConceptScore W3021762060C71924100 @default.
• W3021762060 hasIssue "1" @default.
• W3021762060 hasOpenAccess W3021762060 @default.
• W3021762060 hasRelatedWork W1985888545 @default.
• W3021762060 hasRelatedWork W1994926235 @default.
• W3021762060 hasRelatedWork W2048602311 @default.
• W3021762060 hasRelatedWork W2104203487 @default.
• W3021762060 hasRelatedWork W2126101222 @default.
• W3021762060 hasRelatedWork W2317544342 @default.
• W3021762060 hasRelatedWork W2330646850 @default.
• W3021762060 hasRelatedWork W2590518639 @default.
• W3021762060 hasRelatedWork W2590886028 @default.
• W3021762060 hasRelatedWork W2632285508 @default.
• W3021762060 hasRelatedWork W2749195784 @default.
• W3021762060 hasRelatedWork W2776121293 @default.

• next