FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021781002> ?p ?o ?g. }

• W3021781002 abstract "We report a case of 32–year–old man with myoclonus, rapidly progressive dementia, apraxia, ataxic gait and subtle right hemiparesis. The clinical and first pathological diagnosis was Creutzfeldt Jakob disease. A brain biopsy was obtained from the left temporoparietal area. Autopsy was performed one hour after death. Formalin–fixed, paraffin embedded tissues were used for routine and immunohistochemical microscopic stainings. Part of the autopsy material was fixed in 4% glutaraldehyde in cacodylate buffer for electron microscopy. On microscopic examination apart from neuronal loss and minimal spongiform change the most striking feature was presence of abundant eosinophylic, round, plaques with distinct borders–cotton wool plaques. These plaques were observed in the cerebral cortex, more frequently in the occipital and temporal than frontal lobes. The classic amyloid plaques were also sporadically seen in the cerebral cortex. In cerebellar cortex the cotton wool plaques were also abundant, the classic plaques were sparse in the pyramidal layer. In Congo staining the cotton wool plaques didn't show green birefringence in polarized light. The immunohistochemistry with antibodies for Ab40 and Ab42/43 showed immunoreactivity for the Ab42/43 but not for Ab40 antibody within the cotton wool plaques. The classic plaques showed classical pattern of immunoreactivity by bounding Ab40 and Ab42 in the central core and Ab42/43 in the surrounding. There was also a robust Ab42 and Ab40 immunoreactivity within the cerebral vessel walls especially in cerebellum. There was also a robust Ab42/43 and Ab40 immunoreactivity within the cortical and meningeal vessel walls especially in cerebellum. The immunochemistry shows reactivity for the pathological form of PrP. The most striking ultrastructural feature was presence of dystrophic neuritis with robust autophagic vacuoles. The autophagic vacuoles were also observed in the cell bodies. The clinical history with myoclonus, rapidly progressive dementia in a young man suggested Creutzfeldt Jakob disease. After re–estimation of the whole case the CJD can be excluded and Alzheimer disease with cotton wool plaques must be diagnosed." @default.
• W3021781002 created "2020-05-13" @default.
• W3021781002 creator A5000781573 @default.
• W3021781002 creator A5046753166 @default.
• W3021781002 creator A5086353611 @default.
• W3021781002 date "2006-07-01" @default.
• W3021781002 modified "2023-09-27" @default.
• W3021781002 title "P3-198: A case of early onset Alzheimer's disease with cotton wool plaques but without spastic paraparesis" @default.
• W3021781002 doi "https://doi.org/10.1016/j.jalz.2006.05.1466" @default.
• W3021781002 hasPublicationYear "2006" @default.
• W3021781002 type Work @default.
• W3021781002 sameAs 3021781002 @default.
• W3021781002 citedByCount "0" @default.
• W3021781002 crossrefType "journal-article" @default.
• W3021781002 hasAuthorship W3021781002A5000781573 @default.
• W3021781002 hasAuthorship W3021781002A5046753166 @default.
• W3021781002 hasAuthorship W3021781002A5086353611 @default.
• W3021781002 hasConcept C105702510 @default.
• W3021781002 hasConcept C142724271 @default.
• W3021781002 hasConcept C169760540 @default.
• W3021781002 hasConcept C2777348757 @default.
• W3021781002 hasConcept C2777831001 @default.
• W3021781002 hasConcept C529278444 @default.
• W3021781002 hasConcept C71924100 @default.
• W3021781002 hasConcept C86803240 @default.
• W3021781002 hasConceptScore W3021781002C105702510 @default.
• W3021781002 hasConceptScore W3021781002C142724271 @default.
• W3021781002 hasConceptScore W3021781002C169760540 @default.
• W3021781002 hasConceptScore W3021781002C2777348757 @default.
• W3021781002 hasConceptScore W3021781002C2777831001 @default.
• W3021781002 hasConceptScore W3021781002C529278444 @default.
• W3021781002 hasConceptScore W3021781002C71924100 @default.
• W3021781002 hasConceptScore W3021781002C86803240 @default.
• W3021781002 hasIssue "3S_Part_14" @default.
• W3021781002 hasLocation W30217810021 @default.
• W3021781002 hasOpenAccess W3021781002 @default.
• W3021781002 hasPrimaryLocation W30217810021 @default.
• W3021781002 hasRelatedWork W1974676395 @default.
• W3021781002 hasRelatedWork W1978260998 @default.
• W3021781002 hasRelatedWork W2007926913 @default.
• W3021781002 hasRelatedWork W2058224716 @default.
• W3021781002 hasRelatedWork W2065194738 @default.
• W3021781002 hasRelatedWork W2073016686 @default.
• W3021781002 hasRelatedWork W2074231653 @default.
• W3021781002 hasRelatedWork W2104126845 @default.
• W3021781002 hasRelatedWork W2165744297 @default.
• W3021781002 hasRelatedWork W2557505514 @default.
• W3021781002 hasVolume "2" @default.
• W3021781002 isParatext "false" @default.
• W3021781002 isRetracted "false" @default.
• W3021781002 magId "3021781002" @default.
• W3021781002 workType "article" @default.