FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021796626> ?p ?o ?g. }

• W3021796626 endingPage "105359" @default.
• W3021796626 startingPage "105359" @default.
• W3021796626 abstract "Whole-body physiologically based pharmacokinetic (WB-PBPK) models have become an important tool in drug development, as they enable characterization of pharmacokinetic profiles across different organs based on physiological (systems-specific) and physicochemical (drug-specific) properties. However, it remains unclear which data are needed for accurate predictions when applying the approach to novel candidate molecules progressing into the clinic. In this work, as case study, we investigated the predictive performance of WB-PBPK models both for prospective and retrospective evaluation of the pharmacokinetics of ethambutol, considering scenarios that reflect different stages of development, including settings in which the data are limited to in vitro experiments, in vivo preclinical data, and when some clinical data are available. Overall, the accuracy of PBPK model-predicted systemic and tissue exposure was heavily dependant on prior knowledge about the eliminating organs. Whilst these findings may be specific to ethambutol, the challenges and potential limitations identified here may be relevant to a variety of drugs, raising questions about (1) the minimum requirements for prospective use of WB-PBPK models during the characterization of drug disposition and (2) implication of uncertainty for dose selection in humans." @default.
• W3021796626 created "2020-05-13" @default.
• W3021796626 creator A5002206100 @default.
• W3021796626 creator A5027175809 @default.
• W3021796626 creator A5035120478 @default.
• W3021796626 creator A5080904375 @default.
• W3021796626 creator A5081448028 @default.
• W3021796626 creator A5081960928 @default.
• W3021796626 date "2020-07-01" @default.
• W3021796626 modified "2023-10-12" @default.
• W3021796626 title "Ethambutol disposition in humans: Challenges and limitations of whole-body physiologically-based pharmacokinetic modelling in early drug development" @default.
• W3021796626 cites W100687419 @default.
• W3021796626 cites W1501922076 @default.
• W3021796626 cites W1608678137 @default.
• W3021796626 cites W1930401516 @default.
• W3021796626 cites W1966120422 @default.
• W3021796626 cites W1966821331 @default.
• W3021796626 cites W1970289930 @default.
• W3021796626 cites W1980208682 @default.
• W3021796626 cites W2000710967 @default.
• W3021796626 cites W2005712181 @default.
• W3021796626 cites W2013258146 @default.
• W3021796626 cites W2015249654 @default.
• W3021796626 cites W2027143209 @default.
• W3021796626 cites W2028165836 @default.
• W3021796626 cites W2028523934 @default.
• W3021796626 cites W2045797114 @default.
• W3021796626 cites W2050584750 @default.
• W3021796626 cites W2050819978 @default.
• W3021796626 cites W2082765691 @default.
• W3021796626 cites W2103606212 @default.
• W3021796626 cites W2113830209 @default.
• W3021796626 cites W2115439624 @default.
• W3021796626 cites W2118479851 @default.
• W3021796626 cites W2135772015 @default.
• W3021796626 cites W2137752893 @default.
• W3021796626 cites W2143755040 @default.
• W3021796626 cites W2155881009 @default.
• W3021796626 cites W2165334931 @default.
• W3021796626 cites W2178047135 @default.
• W3021796626 cites W2341647963 @default.
• W3021796626 cites W2463304284 @default.
• W3021796626 cites W2521450174 @default.
• W3021796626 cites W2522795135 @default.
• W3021796626 cites W2558979903 @default.
• W3021796626 cites W2761037621 @default.
• W3021796626 cites W2783299760 @default.
• W3021796626 cites W2884281315 @default.
• W3021796626 cites W2912877386 @default.
• W3021796626 doi "https://doi.org/10.1016/j.ejps.2020.105359" @default.
• W3021796626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32361179" @default.
• W3021796626 hasPublicationYear "2020" @default.
• W3021796626 type Work @default.
• W3021796626 sameAs 3021796626 @default.
• W3021796626 citedByCount "3" @default.
• W3021796626 countsByYear W30217966262021 @default.
• W3021796626 countsByYear W30217966262022 @default.
• W3021796626 countsByYear W30217966262023 @default.
• W3021796626 crossrefType "journal-article" @default.
• W3021796626 hasAuthorship W3021796626A5002206100 @default.
• W3021796626 hasAuthorship W3021796626A5027175809 @default.
• W3021796626 hasAuthorship W3021796626A5035120478 @default.
• W3021796626 hasAuthorship W3021796626A5080904375 @default.
• W3021796626 hasAuthorship W3021796626A5081448028 @default.
• W3021796626 hasAuthorship W3021796626A5081960928 @default.
• W3021796626 hasBestOaLocation W30217966262 @default.
• W3021796626 hasConcept C112705442 @default.
• W3021796626 hasConcept C142724271 @default.
• W3021796626 hasConcept C15744967 @default.
• W3021796626 hasConcept C185867374 @default.
• W3021796626 hasConcept C2776228421 @default.
• W3021796626 hasConcept C2777975735 @default.
• W3021796626 hasConcept C2780035454 @default.
• W3021796626 hasConcept C2781069245 @default.
• W3021796626 hasConcept C38022665 @default.
• W3021796626 hasConcept C64903051 @default.
• W3021796626 hasConcept C71924100 @default.
• W3021796626 hasConcept C77805123 @default.
• W3021796626 hasConcept C98274493 @default.
• W3021796626 hasConceptScore W3021796626C112705442 @default.
• W3021796626 hasConceptScore W3021796626C142724271 @default.
• W3021796626 hasConceptScore W3021796626C15744967 @default.
• W3021796626 hasConceptScore W3021796626C185867374 @default.
• W3021796626 hasConceptScore W3021796626C2776228421 @default.
• W3021796626 hasConceptScore W3021796626C2777975735 @default.
• W3021796626 hasConceptScore W3021796626C2780035454 @default.
• W3021796626 hasConceptScore W3021796626C2781069245 @default.
• W3021796626 hasConceptScore W3021796626C38022665 @default.
• W3021796626 hasConceptScore W3021796626C64903051 @default.
• W3021796626 hasConceptScore W3021796626C71924100 @default.
• W3021796626 hasConceptScore W3021796626C77805123 @default.
• W3021796626 hasConceptScore W3021796626C98274493 @default.
• W3021796626 hasLocation W30217966261 @default.
• W3021796626 hasLocation W30217966262 @default.
• W3021796626 hasLocation W30217966263 @default.
• W3021796626 hasOpenAccess W3021796626 @default.
• W3021796626 hasPrimaryLocation W30217966261 @default.
• W3021796626 hasRelatedWork W2000200648 @default.

• next