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- W3021808963 abstract "Making artificial (“de-novo”) life from completely synthetic molecules is a challenging endeavour that could help us understand life, detect it, and gain some insight on its origins. The aim of this thesis is to combine in a single system several properties that are fundamental to living systems – specifically self-replication, compartmentalization, and metabolism. This work is based on self-replicating fibres that emerge from a dynamic combinatorial library. Through the thesis, we study their self-replication mechanism using HS-AFM, use complex coacervates to compartmentalize them, and combine them with photocatalytic cofactors to obtain the first synthetic example of a light-driven protometabolism. Finally, we combine this protometabolic feedback loop with out-of-equilibrium conditions to design a synthetic oscillator. The results shown here are first steps towards the synthesis of de-novo life, and can lead in the future to more complex processes such as ecological relationships or Darwinian evolution." @default.
- W3021808963 created "2020-05-13" @default.
- W3021808963 creator A5010081709 @default.
- W3021808963 date "2020-06-04" @default.
- W3021808963 modified "2023-10-17" @default.
- W3021808963 title "Steps towards de-novo life: compartmentalization and feedback mechanisms in synthetic self-replicating systems" @default.
- W3021808963 doi "https://doi.org/10.33612/diss.121581426" @default.
- W3021808963 hasPublicationYear "2020" @default.
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