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- W3021811704 abstract "End-stage organ disease affects millions of people around the world, to whom organ transplantation is the only definitive cure available. However, persistent organ shortage and the resulting widespread transplant backlog are part of a disturbing reality and a common burden felt by thousands of patients on waiting lists. Several alternatives and potential solutions to this problem have been sought in the past decades, but one seems particularly promising now, whole-organ bioengineering. This modern alchemy of generating whole-organ scaffolds and recellularizing them with multiple cell types in perfusion bioreactors is paving the way for a new revolution in transplantation medicine. In this chapter, we describe the present status and numerous applications of whole-organ bioengineering, focusing also in the multiple challenges that researchers have to overcome to fully translate these novel technologies into transplantation medicine." @default.
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- W3021811704 date "2016-01-01" @default.
- W3021811704 modified "2023-10-16" @default.
- W3021811704 title "Whole-Organ Bioengineering—Current Tales of Modern Alchemy" @default.
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- W3021811704 doi "https://doi.org/10.1016/b978-0-12-800548-4.00003-6" @default.
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