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- W3021820869 abstract "Much research effort focuses on understanding the thermodynamics, and in particular the efficiency, of molecular-scale machines such as the linear motor kinesin or the rotary F0F1-ATPase. Notably, molecular machines typically operate far from thermodynamic equilibrium, limiting the applicability of equilibrium statistical mechanics. Thermodynamic length analysis, a nonequilibrium framework based on the differential geometry of macroscopic thermodynamics, relates a non-equilibrium property (dissipation) to equilibrium properties (equilibrium fluctuations and their relaxation time). It thus promises a computationally and experimentally tractable method to understand non-equilibrium thermodynamic efficiency. Herein we demonstrate that the thermodynamic length framework follows directly from the assumptions of linear response theory. Uniting these two frameworks promises the dual advantages of providing thermodynamic length analysis a firmer statistical mechanical grounding, and equipping linear response theory with a metric structure to facilitate the prediction and discovery of optimal (minimum dissipation) paths in complicated free energy landscapes. To explore the applicability of this theoretical framework, we examine its accuracy for simple bistable systems, parametrized to model single-molecule force-extension experiments. Through analytic derivation of the equilibrium fluctuations and numerical calculation of the dissipation and relaxation time, we verify that thermodynamic length analysis (though derived in a near-equilibrium limit) provides a strikingly good approximation even far from equilibrium, and thus provides a useful framework for further study of biomolecular motor efficiency." @default.
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- W3021820869 date "2011-02-01" @default.
- W3021820869 modified "2023-10-18" @default.
- W3021820869 title "Thermodynamic Efficiency Out of Equilibrium" @default.
- W3021820869 doi "https://doi.org/10.1016/j.bpj.2010.12.3062" @default.
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