Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021831483> ?p ?o ?g. }
- W3021831483 abstract "The U.S. Agency for Healthcare Research and Quality estimates that there are over 1 million total hip and total knee replacements each year in the U.S. alone. Twenty five percent of those implants will experience aseptic loosening, and bone cement failure is an important part of this. Bone cements are based on poly(methyl methacrylate) (PMMA) systems that are strong but brittle polymers. PMMA-based materials are also essential to modern dental fillings, and likewise, the failure rates are high with lifetimes of 3-10 years. These brittle polymers are an obvious target for self-healing systems which could reduce revision surgeries and visits to dentist. Self-healing polymers have been described in the literature since 1996 and examples from Roman times are known, but their application in medicine has been challenging. This review looks at the development of self-healing biomaterials for these applications and the challenges that lie between development and the clinic. Many of the most promising formulations involve introducing nanoscale components which offer substantial potential benefits over their microscale counterparts especially in composite systems. There is substantial promise for translation, but issues with toxicity, robustness, and reproducibility of these materials in the complex environment of the body must be addressed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Implantable Materials and Surgical Technologies > Nanomaterials and Implants." @default.
- W3021831483 created "2020-05-13" @default.
- W3021831483 creator A5070022086 @default.
- W3021831483 creator A5079335476 @default.
- W3021831483 date "2020-05-02" @default.
- W3021831483 modified "2023-10-10" @default.
- W3021831483 title "Self‐healing biomaterials: The next generation is nano" @default.
- W3021831483 cites W1420516430 @default.
- W3021831483 cites W144948099 @default.
- W3021831483 cites W1526375388 @default.
- W3021831483 cites W1842081459 @default.
- W3021831483 cites W1916545971 @default.
- W3021831483 cites W1938937847 @default.
- W3021831483 cites W1970266744 @default.
- W3021831483 cites W1981961900 @default.
- W3021831483 cites W1982646806 @default.
- W3021831483 cites W1983405414 @default.
- W3021831483 cites W1984330637 @default.
- W3021831483 cites W1986801551 @default.
- W3021831483 cites W1987702644 @default.
- W3021831483 cites W1991230522 @default.
- W3021831483 cites W1991641961 @default.
- W3021831483 cites W1995355277 @default.
- W3021831483 cites W1995703380 @default.
- W3021831483 cites W1999664424 @default.
- W3021831483 cites W2002012608 @default.
- W3021831483 cites W2009176190 @default.
- W3021831483 cites W2017946472 @default.
- W3021831483 cites W2021567012 @default.
- W3021831483 cites W2029454447 @default.
- W3021831483 cites W2030893721 @default.
- W3021831483 cites W2038460995 @default.
- W3021831483 cites W2049304198 @default.
- W3021831483 cites W2051873148 @default.
- W3021831483 cites W2056777003 @default.
- W3021831483 cites W2059142587 @default.
- W3021831483 cites W2081175421 @default.
- W3021831483 cites W2083460218 @default.
- W3021831483 cites W2086449015 @default.
- W3021831483 cites W2086507543 @default.
- W3021831483 cites W2086844883 @default.
- W3021831483 cites W2105440584 @default.
- W3021831483 cites W2118876290 @default.
- W3021831483 cites W2119697999 @default.
- W3021831483 cites W2120674555 @default.
- W3021831483 cites W2121748291 @default.
- W3021831483 cites W2135105627 @default.
- W3021831483 cites W2135298643 @default.
- W3021831483 cites W2137382371 @default.
- W3021831483 cites W2141065279 @default.
- W3021831483 cites W2147566419 @default.
- W3021831483 cites W2149092887 @default.
- W3021831483 cites W2157346754 @default.
- W3021831483 cites W2162813240 @default.
- W3021831483 cites W2167755984 @default.
- W3021831483 cites W2171047363 @default.
- W3021831483 cites W2173450531 @default.
- W3021831483 cites W2215137874 @default.
- W3021831483 cites W2227955616 @default.
- W3021831483 cites W2232503426 @default.
- W3021831483 cites W2238361348 @default.
- W3021831483 cites W2271469487 @default.
- W3021831483 cites W2314344480 @default.
- W3021831483 cites W2322721708 @default.
- W3021831483 cites W2514919446 @default.
- W3021831483 cites W2529000753 @default.
- W3021831483 cites W2610156145 @default.
- W3021831483 cites W2614430826 @default.
- W3021831483 cites W2618461145 @default.
- W3021831483 cites W2619915565 @default.
- W3021831483 cites W2729309989 @default.
- W3021831483 cites W2730325437 @default.
- W3021831483 cites W2736463679 @default.
- W3021831483 cites W2743046660 @default.
- W3021831483 cites W2765492391 @default.
- W3021831483 cites W2795666469 @default.
- W3021831483 cites W2808504153 @default.
- W3021831483 cites W2889714474 @default.
- W3021831483 cites W2890318547 @default.
- W3021831483 cites W2893724653 @default.
- W3021831483 cites W2893763360 @default.
- W3021831483 cites W2894109935 @default.
- W3021831483 cites W3149377315 @default.
- W3021831483 cites W3158833604 @default.
- W3021831483 cites W32470886 @default.
- W3021831483 cites W4236123178 @default.
- W3021831483 cites W4250502606 @default.
- W3021831483 cites W4255418630 @default.
- W3021831483 cites W869614683 @default.
- W3021831483 cites W995505119 @default.
- W3021831483 doi "https://doi.org/10.1002/wnan.1641" @default.
- W3021831483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32359015" @default.
- W3021831483 hasPublicationYear "2020" @default.
- W3021831483 type Work @default.
- W3021831483 sameAs 3021831483 @default.
- W3021831483 citedByCount "12" @default.
- W3021831483 countsByYear W30218314832021 @default.
- W3021831483 countsByYear W30218314832022 @default.
- W3021831483 countsByYear W30218314832023 @default.
- W3021831483 crossrefType "journal-article" @default.