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- W3021832013 abstract "Antigenic variants of visna virus have been compared using the genomic RNA and analyzing the large RNase T1-resistant oligonucleotides. Mutants isolated from a persistently infected sheep contained a small number of changes in their oligonucleotide patterns when compared with parental virus. To determine whether the changes in the nucleotide structure were clustered in one region of the genome, the oligonucleotides of the parental and mutant RNA were ordered along the genome with respect to the 3′ polyadenylated end. All but one difference between the parental strain and the antigenic mutant used for mapping were located within 2 kilobases from the 3′ terminus. The electrophoretic mobilities of some of the oligonucleotides which differed from the parental to the mutant suggest that they might be derived by simple mutation. To determine whether this was how the mutants arose, the complete nucleotide sequence of several oligonucleotides were determined. These analyses showed that a number of the oligonucleotides which were different between the parental and mutant could be accounted for by single base changes." @default.
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- W3021832013 date "1980-01-01" @default.
- W3021832013 modified "2023-09-27" @default.
- W3021832013 title "ANTIGENIC VARIATION OF VISNA VIRUS" @default.
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- W3021832013 doi "https://doi.org/10.1016/b978-0-12-255850-4.50065-2" @default.
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