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• W3021841055 abstract "You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I (MP46)1 Apr 2020MP46-07 BLADDER REMODELING POST-RADIATION INCREASES FIBROSIS AND DECREASES DISTENSIBILITY: IMPLICATIONS FOR PELVIC CANCER SURVIVORS Bernadette M.M. Zwaans, Marissa Grobbel, Elijah P. Ward, Sarah N. Bartolone, Michael B. Chancellor, Nathan R. Tykocki, Sara Roccabianca, and Laura E. Lamb* Bernadette M.M. ZwaansBernadette M.M. Zwaans More articles by this author , Marissa GrobbelMarissa Grobbel More articles by this author , Elijah P. WardElijah P. Ward More articles by this author , Sarah N. BartoloneSarah N. Bartolone More articles by this author , Michael B. ChancellorMichael B. Chancellor More articles by this author , Nathan R. TykockiNathan R. Tykocki More articles by this author , Sara RoccabiancaSara Roccabianca More articles by this author , and Laura E. Lamb*Laura E. Lamb* More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000901.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Radiation cystitis (RC) is a debilitating side effect from pelvic radiation therapy. Histologically, radiation .07therapy causes bladder inflammation, fibrosis and vascular damage. We have previously reported that fibrotic factors (e.g. MMPs and TIMPs) are increased in patients with RC, indicating that bladder remodeling may be occurring. We sought to determine how irradiation and subsequent remodeling of the urinary bladder impacted bladder mechanics in a well-characterized preclinical model of RC. METHODS: Urinary bladders of 8-week-old, C57BL/6 female mice were subjected to irradiation treatment (3 doses of 20 Gy), along with untreated controls. Following treatment, micturition data and body weight were recorded weekly. At 11 weeks post-treatment, the mice were euthanized and their bladders isolated. Some bladders were sectioned and stained with Masson’s trichrome for measurement of collagen area fraction. The extracellular matrices of the remaining bladders were isolated and subjected to a circumferential stress-stretch test. RESULTS: Irradiation of the mice was well-tolerated. Micturition data showed no significant difference between the irradiated and control groups at this early timepoint. However, stress-stretch testing of the isolated extracellular matrix showed a significant decrease in bladder distensibility (Figure 1). Fibrosis of the bladder was indicated by a significant increase in collagen. CONCLUSIONS: Bladder remodeling occurred early after irradiation and negatively affected the mechanical behavior of the bladder through increased fibrosis and decreased distensibility. This occurred prior to significant lower urinary tract symptoms changes or hematuria, both of which are observed in this model. A decrease in bladder distensibility can cause symptoms that interfere with cancer recovery, and also pose a threat to proper kidney function, outlining the importance of studying RC from a mechanical perspective. Source of Funding: This project was in part supported by the U Can-Cer Vive Foundation, the NIDDK K01 career development award (BMMZ; DK114334), NIH K01 DK103840 (NRT), and R01 DK119615 (NRT). © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e675-e676 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Bernadette M.M. Zwaans More articles by this author Marissa Grobbel More articles by this author Elijah P. Ward More articles by this author Sarah N. Bartolone More articles by this author Michael B. Chancellor More articles by this author Nathan R. Tykocki More articles by this author Sara Roccabianca More articles by this author Laura E. Lamb* More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W3021841055 title "MP46-07 BLADDER REMODELING POST-RADIATION INCREASES FIBROSIS AND DECREASES DISTENSIBILITY: IMPLICATIONS FOR PELVIC CANCER SURVIVORS" @default.
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