Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021874920> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3021874920 abstract "X11/mint family proteins contain multiple protein–interaction domains; CASK interaction (CI) domain, munc19 interaction (MI) domain, phospho–tyrosine interaction (PI) domain that binds to APP intracellular domain and two postsynaptic density protein, disc–large, zo–1 (PDZ) domains, that allow them to assemble multiple protein complexes. They regulate APP processing through their interaction with APP and are thought to play synaptic functions through the complexes as synaptic receptor tranport and/or synaptic vesicle exocyotosis. Human X11L2/X11–gamma/mint3 is composed of 575 amino acid residues, is a member of the X11 family and physiologically exhibits ubiquitous expression in several tissues. Here we report that X11L2 interacts with the transcription factor and constitutes the transcriptively active complex with AICD. We demonstrate that, in cultured cells, an X11L2 protein continuously shuttles between the cytoplasm and the nucleus, and its localization is regulated by the specific sequence within X11L2, by laser microscopy technique. We demonstrate that X11L2, likely to FE65, fused with Gal4–DNA binding domain exhibits transcriptional activity and X11L2 activates the transcriptional activity mediated by Gal4–DNA binding domain fused AICD by reporter gene assay. We characterise the Gal4BD–X11L2 mediated transcriptional activity and demonstrate that X11L2 interacts with the transcription factor by co–immuno preciptation assay. Our findings show that Nucleo–cytoplasmic shuttling protein X11L2 plays as a cofactor of the transcription factor mediated gene transactivation and is siginificant for AICD mediated RIP signaling." @default.
- W3021874920 created "2020-05-13" @default.
- W3021874920 creator A5033313384 @default.
- W3021874920 creator A5087185797 @default.
- W3021874920 date "2006-07-01" @default.
- W3021874920 modified "2023-09-27" @default.
- W3021874920 title "P1-411: Nucleo-cytoplasmic shuttling X11L2/X11gamma/mint3 constitutes the transcriptively active complex with AICD" @default.
- W3021874920 doi "https://doi.org/10.1016/j.jalz.2006.05.790" @default.
- W3021874920 hasPublicationYear "2006" @default.
- W3021874920 type Work @default.
- W3021874920 sameAs 3021874920 @default.
- W3021874920 citedByCount "0" @default.
- W3021874920 crossrefType "journal-article" @default.
- W3021874920 hasAuthorship W3021874920A5033313384 @default.
- W3021874920 hasAuthorship W3021874920A5087185797 @default.
- W3021874920 hasBestOaLocation W30218749201 @default.
- W3021874920 hasConcept C104317684 @default.
- W3021874920 hasConcept C11804247 @default.
- W3021874920 hasConcept C1292079 @default.
- W3021874920 hasConcept C138885662 @default.
- W3021874920 hasConcept C154428179 @default.
- W3021874920 hasConcept C170493617 @default.
- W3021874920 hasConcept C179926584 @default.
- W3021874920 hasConcept C183786373 @default.
- W3021874920 hasConcept C185592680 @default.
- W3021874920 hasConcept C187541742 @default.
- W3021874920 hasConcept C190062978 @default.
- W3021874920 hasConcept C197341189 @default.
- W3021874920 hasConcept C41895202 @default.
- W3021874920 hasConcept C55493867 @default.
- W3021874920 hasConcept C62478195 @default.
- W3021874920 hasConcept C86339819 @default.
- W3021874920 hasConcept C86803240 @default.
- W3021874920 hasConcept C95444343 @default.
- W3021874920 hasConceptScore W3021874920C104317684 @default.
- W3021874920 hasConceptScore W3021874920C11804247 @default.
- W3021874920 hasConceptScore W3021874920C1292079 @default.
- W3021874920 hasConceptScore W3021874920C138885662 @default.
- W3021874920 hasConceptScore W3021874920C154428179 @default.
- W3021874920 hasConceptScore W3021874920C170493617 @default.
- W3021874920 hasConceptScore W3021874920C179926584 @default.
- W3021874920 hasConceptScore W3021874920C183786373 @default.
- W3021874920 hasConceptScore W3021874920C185592680 @default.
- W3021874920 hasConceptScore W3021874920C187541742 @default.
- W3021874920 hasConceptScore W3021874920C190062978 @default.
- W3021874920 hasConceptScore W3021874920C197341189 @default.
- W3021874920 hasConceptScore W3021874920C41895202 @default.
- W3021874920 hasConceptScore W3021874920C55493867 @default.
- W3021874920 hasConceptScore W3021874920C62478195 @default.
- W3021874920 hasConceptScore W3021874920C86339819 @default.
- W3021874920 hasConceptScore W3021874920C86803240 @default.
- W3021874920 hasConceptScore W3021874920C95444343 @default.
- W3021874920 hasIssue "3S_Part_8" @default.
- W3021874920 hasLocation W30218749201 @default.
- W3021874920 hasOpenAccess W3021874920 @default.
- W3021874920 hasPrimaryLocation W30218749201 @default.
- W3021874920 hasRelatedWork W1562116524 @default.
- W3021874920 hasRelatedWork W1897589155 @default.
- W3021874920 hasRelatedWork W1945374317 @default.
- W3021874920 hasRelatedWork W2004092485 @default.
- W3021874920 hasRelatedWork W2028122019 @default.
- W3021874920 hasRelatedWork W2411147949 @default.
- W3021874920 hasRelatedWork W2421368074 @default.
- W3021874920 hasRelatedWork W2969822612 @default.
- W3021874920 hasRelatedWork W3151480201 @default.
- W3021874920 hasRelatedWork W2388815579 @default.
- W3021874920 hasVolume "2" @default.
- W3021874920 isParatext "false" @default.
- W3021874920 isRetracted "false" @default.
- W3021874920 magId "3021874920" @default.
- W3021874920 workType "article" @default.