Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021902771> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3021902771 endingPage "118" @default.
- W3021902771 startingPage "113" @default.
- W3021902771 abstract "BACKGROUND: Endometrial cancer is the most common cancer of the female genital tract. No effective biomarkers currently exist to allow for an efficient risk classification of endometrial carcinoma or to direct treatment (adjuvant radiation and/or chemotherapy) or to triage pelvic and para-aortic lymphadenectomy. L1 cell adhesion molecule (L1CAM) a transmembrane protein of the immunoglobulin family that has been implicated in promoting tumor cell proliferation, migration, invasion, and metastasis became an attractive candidate as a potential biomarker in endometrial carcinoma and potential therapeutic target in high-risk groups.
 OBJECTIVES: Evaluation of L1CAM expression in endometrial carcinoma and correlation of this expression with various pathological parameters.
 MATERIALS AND METHODS: Immunohistochemical staining for L1CAM was performed on paraffin-embedded sections of 80 cases of endometrial carcinomas that underwent total hysterectomy with bilateral salpingo-oophorectomy. Expression of L1CAM in >10% of tumor cells was interpreted as positive.
 RESULTS: L1CAM expression was detected in 22.5% of cases and showed statistically significant correlation with non-endometrioid histological type, high grade, high FIGO stage, high pathological (T) stage, cervical involvement, nodal metastasis, lymphovascular space invasion, and high-risk tumor according to the European Society for Medical Oncology system for risk stratification (p < 0.05).
 CONCLUSION: The high rate of L1CAM expression in high-risk endometrial carcinomas suggests that L1CAM represents a potential marker for the identification of patients needing closer follow-up and aggressive treatment. In addition, its potential role as a therapeutic target for high-risk endometrial cancer seems promising." @default.
- W3021902771 created "2020-05-13" @default.
- W3021902771 creator A5010786828 @default.
- W3021902771 creator A5030713283 @default.
- W3021902771 creator A5032853903 @default.
- W3021902771 creator A5059446441 @default.
- W3021902771 date "2020-04-15" @default.
- W3021902771 modified "2023-09-27" @default.
- W3021902771 title "Immunohistochemical Expression of “L1 cell Adhesion Molecule” in Endometrial Carcinomas" @default.
- W3021902771 cites W1994046098 @default.
- W3021902771 cites W2111467397 @default.
- W3021902771 cites W2262284635 @default.
- W3021902771 cites W2286299792 @default.
- W3021902771 cites W2298858873 @default.
- W3021902771 cites W2511088334 @default.
- W3021902771 cites W2532858212 @default.
- W3021902771 cites W2533653021 @default.
- W3021902771 cites W2709458048 @default.
- W3021902771 cites W2741017563 @default.
- W3021902771 cites W2782741600 @default.
- W3021902771 cites W2819186165 @default.
- W3021902771 cites W2883924148 @default.
- W3021902771 cites W2900589018 @default.
- W3021902771 cites W2906684287 @default.
- W3021902771 cites W2938552003 @default.
- W3021902771 cites W2942618635 @default.
- W3021902771 doi "https://doi.org/10.3889/oamjms.2020.4633" @default.
- W3021902771 hasPublicationYear "2020" @default.
- W3021902771 type Work @default.
- W3021902771 sameAs 3021902771 @default.
- W3021902771 citedByCount "0" @default.
- W3021902771 crossrefType "journal-article" @default.
- W3021902771 hasAuthorship W3021902771A5010786828 @default.
- W3021902771 hasAuthorship W3021902771A5030713283 @default.
- W3021902771 hasAuthorship W3021902771A5032853903 @default.
- W3021902771 hasAuthorship W3021902771A5059446441 @default.
- W3021902771 hasConcept C121608353 @default.
- W3021902771 hasConcept C126322002 @default.
- W3021902771 hasConcept C142724271 @default.
- W3021902771 hasConcept C143998085 @default.
- W3021902771 hasConcept C146357865 @default.
- W3021902771 hasConcept C151730666 @default.
- W3021902771 hasConcept C204232928 @default.
- W3021902771 hasConcept C206592519 @default.
- W3021902771 hasConcept C2776677690 @default.
- W3021902771 hasConcept C2777088508 @default.
- W3021902771 hasConcept C2777546739 @default.
- W3021902771 hasConcept C2779013556 @default.
- W3021902771 hasConcept C2780824555 @default.
- W3021902771 hasConcept C2994532551 @default.
- W3021902771 hasConcept C71924100 @default.
- W3021902771 hasConcept C86803240 @default.
- W3021902771 hasConceptScore W3021902771C121608353 @default.
- W3021902771 hasConceptScore W3021902771C126322002 @default.
- W3021902771 hasConceptScore W3021902771C142724271 @default.
- W3021902771 hasConceptScore W3021902771C143998085 @default.
- W3021902771 hasConceptScore W3021902771C146357865 @default.
- W3021902771 hasConceptScore W3021902771C151730666 @default.
- W3021902771 hasConceptScore W3021902771C204232928 @default.
- W3021902771 hasConceptScore W3021902771C206592519 @default.
- W3021902771 hasConceptScore W3021902771C2776677690 @default.
- W3021902771 hasConceptScore W3021902771C2777088508 @default.
- W3021902771 hasConceptScore W3021902771C2777546739 @default.
- W3021902771 hasConceptScore W3021902771C2779013556 @default.
- W3021902771 hasConceptScore W3021902771C2780824555 @default.
- W3021902771 hasConceptScore W3021902771C2994532551 @default.
- W3021902771 hasConceptScore W3021902771C71924100 @default.
- W3021902771 hasConceptScore W3021902771C86803240 @default.
- W3021902771 hasIssue "A" @default.
- W3021902771 hasLocation W30219027711 @default.
- W3021902771 hasOpenAccess W3021902771 @default.
- W3021902771 hasPrimaryLocation W30219027711 @default.
- W3021902771 hasRelatedWork W2353600181 @default.
- W3021902771 hasRelatedWork W2370276540 @default.
- W3021902771 hasRelatedWork W2653826832 @default.
- W3021902771 hasRelatedWork W2734526255 @default.
- W3021902771 hasRelatedWork W2742519752 @default.
- W3021902771 hasRelatedWork W3021902771 @default.
- W3021902771 hasRelatedWork W4213226798 @default.
- W3021902771 hasRelatedWork W4231803726 @default.
- W3021902771 hasRelatedWork W4236508691 @default.
- W3021902771 hasRelatedWork W4250091167 @default.
- W3021902771 hasVolume "8" @default.
- W3021902771 isParatext "false" @default.
- W3021902771 isRetracted "false" @default.
- W3021902771 magId "3021902771" @default.
- W3021902771 workType "article" @default.