Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021904298> ?p ?o ?g. }
- W3021904298 endingPage "112334" @default.
- W3021904298 startingPage "112334" @default.
- W3021904298 abstract "More effective prophylactic and therapeutic strategies to combat influenza viruses are urgently required worldwide because the conventional anti-influenza drugs are facing drug resistance. Here, dihydropyrrolidones (DHPs), the products of an efficient multi-components reaction, were found to possess good activities against influenza A virus (IAV). Primary structure-activity relationship indicated that the activities of DHPs were greatly influenced by substituents and four of them had IC50 values lower than 10 μM (DHPs 5–2, 8, 14 and 19: IC50 = 3.11–9.23 μM). The activities against multiple IAV strains and mechanism of DHPs were further investigated by using 5–2 (IC50 = 3.11 μM). It was found that 5–2 possessed antiviral effects against all the investigated subtypes of IAVs with the IC50 values from 3.11 to 7.13 μM. Moreover, 5–2 showed very low cytotoxicity with CC50 > 400 μM. Results of mechanism study indicated that 5–2 could efficiently inhibit replication of IAV, up-regulate the expression of key antiviral cytokines IFN-β and antiviral protein MxA, and suppress the production of the NDAPH oxidase NOX1 in MDCK cells. These results indicated that 5–2 could be used as a potential inhibitor against wide subtypes of IAVs." @default.
- W3021904298 created "2020-05-13" @default.
- W3021904298 creator A5007166166 @default.
- W3021904298 creator A5011140295 @default.
- W3021904298 creator A5014962959 @default.
- W3021904298 creator A5019499954 @default.
- W3021904298 creator A5027000439 @default.
- W3021904298 creator A5036630106 @default.
- W3021904298 creator A5043942666 @default.
- W3021904298 creator A5061671556 @default.
- W3021904298 creator A5088170766 @default.
- W3021904298 date "2020-08-01" @default.
- W3021904298 modified "2023-10-16" @default.
- W3021904298 title "Discovery of dihydropyrrolidones as novel inhibitors against influenza A virus" @default.
- W3021904298 cites W1568631174 @default.
- W3021904298 cites W1968528271 @default.
- W3021904298 cites W1978779484 @default.
- W3021904298 cites W2002258763 @default.
- W3021904298 cites W2040955501 @default.
- W3021904298 cites W2043717892 @default.
- W3021904298 cites W2066303715 @default.
- W3021904298 cites W2074097848 @default.
- W3021904298 cites W2093455641 @default.
- W3021904298 cites W2112170460 @default.
- W3021904298 cites W2118548271 @default.
- W3021904298 cites W2130296275 @default.
- W3021904298 cites W2143027468 @default.
- W3021904298 cites W2143717515 @default.
- W3021904298 cites W2158112812 @default.
- W3021904298 cites W2323471225 @default.
- W3021904298 cites W2336451601 @default.
- W3021904298 cites W2460844087 @default.
- W3021904298 cites W2535582297 @default.
- W3021904298 cites W2567412275 @default.
- W3021904298 cites W2593658481 @default.
- W3021904298 cites W2604362483 @default.
- W3021904298 cites W2605465129 @default.
- W3021904298 cites W2737480209 @default.
- W3021904298 cites W2751683433 @default.
- W3021904298 cites W2756024829 @default.
- W3021904298 cites W2766504208 @default.
- W3021904298 cites W2771130612 @default.
- W3021904298 cites W2775569101 @default.
- W3021904298 cites W2887243299 @default.
- W3021904298 cites W2911530530 @default.
- W3021904298 cites W2940548694 @default.
- W3021904298 cites W2951773227 @default.
- W3021904298 cites W2968462744 @default.
- W3021904298 cites W2980571891 @default.
- W3021904298 cites W2985021031 @default.
- W3021904298 doi "https://doi.org/10.1016/j.ejmech.2020.112334" @default.
- W3021904298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32408213" @default.
- W3021904298 hasPublicationYear "2020" @default.
- W3021904298 type Work @default.
- W3021904298 sameAs 3021904298 @default.
- W3021904298 citedByCount "9" @default.
- W3021904298 countsByYear W30219042982021 @default.
- W3021904298 countsByYear W30219042982022 @default.
- W3021904298 countsByYear W30219042982023 @default.
- W3021904298 crossrefType "journal-article" @default.
- W3021904298 hasAuthorship W3021904298A5007166166 @default.
- W3021904298 hasAuthorship W3021904298A5011140295 @default.
- W3021904298 hasAuthorship W3021904298A5014962959 @default.
- W3021904298 hasAuthorship W3021904298A5019499954 @default.
- W3021904298 hasAuthorship W3021904298A5027000439 @default.
- W3021904298 hasAuthorship W3021904298A5036630106 @default.
- W3021904298 hasAuthorship W3021904298A5043942666 @default.
- W3021904298 hasAuthorship W3021904298A5061671556 @default.
- W3021904298 hasAuthorship W3021904298A5088170766 @default.
- W3021904298 hasConcept C104317684 @default.
- W3021904298 hasConcept C109316439 @default.
- W3021904298 hasConcept C140704245 @default.
- W3021904298 hasConcept C159047783 @default.
- W3021904298 hasConcept C185592680 @default.
- W3021904298 hasConcept C202751555 @default.
- W3021904298 hasConcept C203014093 @default.
- W3021904298 hasConcept C2522874641 @default.
- W3021904298 hasConcept C2777546802 @default.
- W3021904298 hasConcept C2777752497 @default.
- W3021904298 hasConcept C2778048844 @default.
- W3021904298 hasConcept C2778371730 @default.
- W3021904298 hasConcept C2780866276 @default.
- W3021904298 hasConcept C55493867 @default.
- W3021904298 hasConcept C74187038 @default.
- W3021904298 hasConcept C77957584 @default.
- W3021904298 hasConcept C86803240 @default.
- W3021904298 hasConcept C89423630 @default.
- W3021904298 hasConceptScore W3021904298C104317684 @default.
- W3021904298 hasConceptScore W3021904298C109316439 @default.
- W3021904298 hasConceptScore W3021904298C140704245 @default.
- W3021904298 hasConceptScore W3021904298C159047783 @default.
- W3021904298 hasConceptScore W3021904298C185592680 @default.
- W3021904298 hasConceptScore W3021904298C202751555 @default.
- W3021904298 hasConceptScore W3021904298C203014093 @default.
- W3021904298 hasConceptScore W3021904298C2522874641 @default.
- W3021904298 hasConceptScore W3021904298C2777546802 @default.
- W3021904298 hasConceptScore W3021904298C2777752497 @default.
- W3021904298 hasConceptScore W3021904298C2778048844 @default.