FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021925090> ?p ?o ?g. }

• W3021925090 endingPage "649" @default.
• W3021925090 startingPage "639" @default.
• W3021925090 abstract "Abstract The therapies for food allergy (FA) need to be improved. The generation of inducible regulatory T cells (Tregs) can support immune tolerance in the body. This study aims to suppress experimental FA by inducing Tregs through the employment of modified exosomes (mExosomes). In this study, mExosomes were prepared by incubating dendritic cells with interleukin (IL)‐2 and ovalbumin (OVA, used as a specific antigen) in the culture. Exosomes were purified from culture supernatant and used as the mExosomes. A murine FA model was developed to test the effects of mExosomes on the generation of Tregs in the mouse intestinal tissues and inhibiting FA. The results showed that mExosomes, which carried IL‐2 and a complex of OVA peptide–major histocompatibility complex class II on the surface of exosomes, bound to OVA‐specific CD4 + T cells and induced CD4 + T cells to differentiate into Tregs. In the FA mouse intestinal tissues, we found low IL‐2 levels that were positively correlated with the number of Tregs. Depletion of IL‐2 in mice prevented the generation of Tregs. The levels of peroxisome proliferator‐activated receptor‐γ were increased in the FA intestinal tissues with inhibited IL‐2 production. Administration of mExosomes induced Tregs in the intestinal tissues and efficiently suppressed FA in mice. We conclude that the mExosomes can suppress FA in mice through inducing Tregs. The data suggest that the mExosomes have translational potential in the treatment of FA and other allergic disorders." @default.
• W3021925090 created "2020-05-13" @default.
• W3021925090 creator A5005117527 @default.
• W3021925090 creator A5006901857 @default.
• W3021925090 creator A5009638692 @default.
• W3021925090 creator A5038186143 @default.
• W3021925090 creator A5048704192 @default.
• W3021925090 creator A5056037630 @default.
• W3021925090 creator A5058569786 @default.
• W3021925090 creator A5060341807 @default.
• W3021925090 creator A5071991576 @default.
• W3021925090 creator A5079027970 @default.
• W3021925090 date "2020-07-15" @default.
• W3021925090 modified "2023-10-16" @default.
• W3021925090 title "Specific antigen‐guiding exosomes inhibit food allergies by inducing regulatory T cells" @default.
• W3021925090 cites W1511195742 @default.
• W3021925090 cites W1996945569 @default.
• W3021925090 cites W2007565796 @default.
• W3021925090 cites W2029722254 @default.
• W3021925090 cites W2061017694 @default.
• W3021925090 cites W2088490984 @default.
• W3021925090 cites W2088691398 @default.
• W3021925090 cites W2093797523 @default.
• W3021925090 cites W2097251306 @default.
• W3021925090 cites W2131018850 @default.
• W3021925090 cites W2235440013 @default.
• W3021925090 cites W2259033521 @default.
• W3021925090 cites W2418462204 @default.
• W3021925090 cites W2545836320 @default.
• W3021925090 cites W2738367665 @default.
• W3021925090 cites W2740495409 @default.
• W3021925090 cites W2765319000 @default.
• W3021925090 cites W2768241957 @default.
• W3021925090 cites W2770868505 @default.
• W3021925090 cites W2790089204 @default.
• W3021925090 cites W2791003234 @default.
• W3021925090 cites W2794120108 @default.
• W3021925090 cites W2809899259 @default.
• W3021925090 cites W2903295289 @default.
• W3021925090 cites W2912090594 @default.
• W3021925090 cites W2912100273 @default.
• W3021925090 cites W2940102262 @default.
• W3021925090 cites W843905707 @default.
• W3021925090 doi "https://doi.org/10.1111/imcb.12347" @default.
• W3021925090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32378751" @default.
• W3021925090 hasPublicationYear "2020" @default.
• W3021925090 type Work @default.
• W3021925090 sameAs 3021925090 @default.
• W3021925090 citedByCount "6" @default.
• W3021925090 countsByYear W30219250902021 @default.
• W3021925090 countsByYear W30219250902022 @default.
• W3021925090 countsByYear W30219250902023 @default.
• W3021925090 crossrefType "journal-article" @default.
• W3021925090 hasAuthorship W3021925090A5005117527 @default.
• W3021925090 hasAuthorship W3021925090A5006901857 @default.
• W3021925090 hasAuthorship W3021925090A5009638692 @default.
• W3021925090 hasAuthorship W3021925090A5038186143 @default.
• W3021925090 hasAuthorship W3021925090A5048704192 @default.
• W3021925090 hasAuthorship W3021925090A5056037630 @default.
• W3021925090 hasAuthorship W3021925090A5058569786 @default.
• W3021925090 hasAuthorship W3021925090A5060341807 @default.
• W3021925090 hasAuthorship W3021925090A5071991576 @default.
• W3021925090 hasAuthorship W3021925090A5079027970 @default.
• W3021925090 hasConcept C104317684 @default.
• W3021925090 hasConcept C145059251 @default.
• W3021925090 hasConcept C147483822 @default.
• W3021925090 hasConcept C185592680 @default.
• W3021925090 hasConcept C203014093 @default.
• W3021925090 hasConcept C20518536 @default.
• W3021925090 hasConcept C207480886 @default.
• W3021925090 hasConcept C2776946954 @default.
• W3021925090 hasConcept C55493867 @default.
• W3021925090 hasConcept C86803240 @default.
• W3021925090 hasConcept C8891405 @default.
• W3021925090 hasConceptScore W3021925090C104317684 @default.
• W3021925090 hasConceptScore W3021925090C145059251 @default.
• W3021925090 hasConceptScore W3021925090C147483822 @default.
• W3021925090 hasConceptScore W3021925090C185592680 @default.
• W3021925090 hasConceptScore W3021925090C203014093 @default.
• W3021925090 hasConceptScore W3021925090C20518536 @default.
• W3021925090 hasConceptScore W3021925090C207480886 @default.
• W3021925090 hasConceptScore W3021925090C2776946954 @default.
• W3021925090 hasConceptScore W3021925090C55493867 @default.
• W3021925090 hasConceptScore W3021925090C86803240 @default.
• W3021925090 hasConceptScore W3021925090C8891405 @default.
• W3021925090 hasIssue "8" @default.
• W3021925090 hasLocation W30219250901 @default.
• W3021925090 hasOpenAccess W3021925090 @default.
• W3021925090 hasPrimaryLocation W30219250901 @default.
• W3021925090 hasRelatedWork W1972479046 @default.
• W3021925090 hasRelatedWork W2017177540 @default.
• W3021925090 hasRelatedWork W2033998433 @default.
• W3021925090 hasRelatedWork W2054188263 @default.
• W3021925090 hasRelatedWork W2220102944 @default.
• W3021925090 hasRelatedWork W2409441623 @default.
• W3021925090 hasRelatedWork W2764269354 @default.
• W3021925090 hasRelatedWork W2945667128 @default.
• W3021925090 hasRelatedWork W3109192410 @default.

• next