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- W3021928953 abstract "Abstract Continued improvements in cancer therapies have increased the number of long-term cancer survivors. Radiation therapy remains one of the primary treatment modalities with about 60% of newly diagnosed cancer patients receiving radiation during the course of their disease. While radiation therapy has dramatically improved patient survival in a number of cancer types, the late effects remain a significant factor affecting the quality of life particularly in pediatric patients. Radiation-induced brain injury can result in cognitive dysfunction, including hippocampal-related learning and memory dysfunction that can escalate to dementia. In this article, we review the current understanding of the mechanisms behind radiation-induced brain injury focusing on the role of neuroinflammation and reduced hippocampal neurogenesis. Approaches to prevent or ameliorate treatment-induced side effects are also discussed along with remaining challenges in the field." @default.
- W3021928953 created "2020-05-13" @default.
- W3021928953 creator A5023448259 @default.
- W3021928953 creator A5050126669 @default.
- W3021928953 creator A5066170926 @default.
- W3021928953 date "2020-01-01" @default.
- W3021928953 modified "2023-10-12" @default.
- W3021928953 title "Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation" @default.
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