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- W3021933931 abstract "Stomatitis and related oral pain are sequelae of peripheral blood stem cell transplantation (PBSCT) chemotherapy (CT). This pilot study measured multiple dimensions of stomatitis-related oropharyngeal pain and TNFα expression in buccal mucosa of PBSCT patients pre/post CT. Research instruments included Oral Mucositis Assessment Scale, and Painometer®. Buccal brush biopsy samples were processed by TRIzol only (TRI-O) (N= 46), and RLT-TRIzol (RLT-TRI) (N= 24). Real time PCR, employing complete controls and reference plasmids, for human TNFα showed expression below detection threshold in the RLT-TRI group. Matched TRI-O samples showed mRNA copy numbers of 102 to 104, suggesting that TRI-O is the preferred method for buccal RNA. Male and female subjects (N= 24), mean age 46 years, primarily Caucasian, with late stage cancer diagnoses, received one of five PBSCT protocols. Stomatitis-related oral pain data were analyzed for 23 subjects. Stomatitis severity varied with treatment protocol and was observed in 18 subjects post CT (mean= 5.26). Subjects reported higher levels of pain on swallowing (n= 10; mean= 2.38). Stomatitis severity was significantly positively correlated with oral pain intensity (p< .01), and oral pain intensity and worst intensity with swallowing (p< .001). Buccal mucosa TNFα expression ranged from 42 to 15300 copies. Fourteen subjects had measurable increases in TNFα expression post CT via TRI-O method. Significant positive correlations were seen between TNFα concentrations and pain dimensions: overall intensity (p< .05); worst intensity (p< .01); and overall (p< .05) and worst intensity with swallowing (p< .01).Validity of a unique, sensitive assay for gene expression from buccal brushing was demonstrated. The data pose intriguing questions about the suitability of the local inflammatory response as a target for topical interventions. Stomatitis-related oral pain remains a complex multidimensional experience that needs further elucidation through clinical research." @default.
- W3021933931 created "2020-05-13" @default.
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- W3021933931 date "2006-04-01" @default.
- W3021933931 modified "2023-09-26" @default.
- W3021933931 title "(709)" @default.
- W3021933931 doi "https://doi.org/10.1016/j.jpain.2006.01.111" @default.
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