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- W3021946623 abstract "The immunological rejection of transplanted tissues and organs is one of the major problems in organ replacement, and immunosuppression still carries significant long-term side effects. One solution may reside in novel therapeutic strategies that strive to prevent the need for long-term and high dose immunosuppression. These strategies involve immunologically modifying the foreign proteins on cells and tissues from the donor, instead of treating the host. This technology is sometimes referred to as ’donor antigen modification’ or, more stylistically, ’designer tissue and organs’. The purpose of this chapter is to describe the evolution of research into designer tissues, and to trace its contribution to a growing body of transplant research.Variations on the designer tissue concept are being probed in animal models of diabetes, solid organ failure, and neurological diseases. A concept launched in the laboratory in the early 1990s has already culminated in landmark human clinical trials for Parkinson’s and Huntington’s disease using donor-modified pig neurons into humans." @default.
- W3021946623 created "2020-05-13" @default.
- W3021946623 creator A5084645268 @default.
- W3021946623 date "2014-01-01" @default.
- W3021946623 modified "2023-09-24" @default.
- W3021946623 title "Immunomodulation" @default.
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- W3021946623 doi "https://doi.org/10.1016/b978-0-12-398358-9.00027-6" @default.
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